O¹-benzyl O⁴-(tert-butyl) (R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate

Base Information

• Chemical Name: O¹-benzyl O⁴-(tert-butyl) (R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate
• CAS No.: 1217813-68-7
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.415

Synonyms:O¹-benzyl O⁴-(tert-butyl) (R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate

Chemical Property of O¹-benzyl O⁴-(tert-butyl) (R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-Hydroxymethyl-piperazine-1,4-dicarboxylicacid1-benzylester4-tert-butylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of O¹-benzyl O⁴-(tert-butyl) (R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate

There total 1 articles about O¹-benzyl O⁴-(tert-butyl) (R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate (278788-66-2) + benzyl chloroformate (501-53-1,94274-21-2) → O1-benzyl O4-(tert-butyl) (R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1217813-68-7,529516-61-8)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; at 0 - 10 ℃; for 5.5h;

Reference yield: 100.0%

O1-benzyl O4-(tert-butyl) (R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1217813-68-7,529516-61-8) + methanesulfonyl chloride (124-63-0) → O1-benzyl O4tert-butyl (2R)-2-(methylsulfonyloxymethyl)piperazine-1,4-dicarboxylate

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.333333h;

Reference yield:

O1-benzyl O4-(tert-butyl) (R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1217813-68-7,529516-61-8) → (R)-1-benzyl 4-tert-butyl 2-formylpiperazine-1,4-dicarboxylate (1381949-87-6)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2012.04.118

upstream raw materials:

(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate

benzyl chloroformate

Downstream raw materials:

C₂₉H₃₇Cl₂N₅O₅

C₂₇H₃₅Cl₂N₅O₃

(R)-1-benzyl 4-tert-butyl 2-formylpiperazine-1,4-dicarboxylate

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