2-[(3',4'-dichlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Base Information

Chemical Name:2-[(3',4'-dichlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid
CAS No.:1369962-28-6
Molecular Formula:C₂₄H₂₀Cl₂N₄O₅S
Molecular Weight:547.419
Hs Code.:

Synonyms:2-[(3',4'-dichlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

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Chemical Property of 2-[(3',4'-dichlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

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Technology Process of 2-[(3',4'-dichlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

There total 9 articles about 2-[(3',4'-dichlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369963-30-3
N-(3',4'-dichlorobiphenyl-4-yl)-N-[1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butan-2-yl]methanesulfonamide

: 1369962-28-6
2-[(3',4'-dichlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Guidance literature:: With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In water; acetonitrile; at 35 ℃; for 6h;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1369962-28-6
2-[(3',4'-dichlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 1 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

4: potassium carbonate; methanol / 1 h / 20 °C

5: sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile; water / 6 h / 35 °C

With pyridine; methanol; sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 4284-50-8
N-(4-bromophenyl)methanesulfonamide

: 1369962-28-6
2-[(3',4'-dichlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

3: potassium carbonate; methanol / 1 h / 20 °C

4: sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile; water / 6 h / 35 °C

With methanol; sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;