9-(5-O-trityl-3-O-methylthiothiocarbonyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine

Base Information

Chemical Name:9-(5-O-trityl-3-O-methylthiothiocarbonyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine
CAS No.:265987-43-7
Molecular Formula:C₃₁H₂₈FN₅O₃S₂
Molecular Weight:601.725
Hs Code.:

Synonyms:9-(5-O-trityl-3-O-methylthiothiocarbonyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine

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Chemical Property of 9-(5-O-trityl-3-O-methylthiothiocarbonyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine

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Technology Process of 9-(5-O-trityl-3-O-methylthiothiocarbonyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine

There total 11 articles about 9-(5-O-trityl-3-O-methylthiothiocarbonyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.6%

: 75-15-0,12122-00-8
carbon disulfide

: 239811-11-1
9-(5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

: 74-88-4
methyl iodide

: 265987-43-7
9-(5-O-trityl-3-O-methylthiothiocarbonyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine

Guidance literature:: carbon disulfide; 9-(5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine; With sodium hydroxide; In dimethyl sulfoxide; at 15 ℃; for 0.25h;

methyl iodide;
DOI:10.1016/S0040-4039(01)01617-3

Reference yield: 72.2%

: 265987-43-7
9-(5-O-trityl-3-O-methylthiothiocarbonyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine

Guidance literature:

Reference yield:

: 76-83-5
trityl chloride

: 265987-43-7
9-(5-O-trityl-3-O-methylthiothiocarbonyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 38 percent / DMAP / CH₂Cl₂

2.1: pyridine / toluene

2.2: 70 percent / Et₃N / toluene

3.1: 78 percent / (diethylamino)sulfur trifluoride; pyridine / CH₂Cl₂ / Heating

4.1: 98 percent / NH₃ / methanol

5.1: NaOH / dimethylsulfoxide

With pyridine; dmap; sodium hydroxide; diethylamino-sulfur trifluoride; ammonia; In methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1081/NCN-120021951