N-3-[(diisopropoxyphosphoryl)methyl]-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-5-azacytosine

Base Information

Chemical Name:N-3-[(diisopropoxyphosphoryl)methyl]-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-5-azacytosine
CAS No.:933460-59-4
Molecular Formula:C₃₂H₃₉N₄O₆P
Molecular Weight:606.659
Hs Code.:

Synonyms:N-3-[(diisopropoxyphosphoryl)methyl]-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-5-azacytosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-3-[(diisopropoxyphosphoryl)methyl]-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-5-azacytosine

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Technology Process of N-3-[(diisopropoxyphosphoryl)methyl]-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-5-azacytosine

There total 2 articles about N-3-[(diisopropoxyphosphoryl)methyl]-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-5-azacytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 933460-54-9
1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-5-azacytosine

: 98432-80-5
diisopropyl (bromomethyl)phosphonate

: 933460-58-3
1-{(2S)-2-[(diisopropoxyphosphoryl)methoxy-3-(triphenylmethoxy)]propyl}-5-azacytosine

: 933460-59-4
N-3-[(diisopropoxyphosphoryl)methyl]-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-5-azacytosine

Guidance literature:: With sodium t-butanolate; In 1,4-dioxane; at 80 ℃;
DOI:10.1021/jm061281+

Reference yield:

: 129940-50-7
(S)-tritylglycidol

: 933460-59-4
N-3-[(diisopropoxyphosphoryl)methyl]-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]-5-azacytosine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / sodium hydroxide / dimethylsulfoxide / 10 h / 120 °C

2: 18 percent / sodium tert-butoxide / dioxane / 80 °C

With sodium hydroxide; sodium t-butanolate; In 1,4-dioxane; dimethyl sulfoxide;
DOI:10.1021/jm061281+