[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-dihydroxy-cyclohexyl ester

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Chemical Name:[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-dihydroxy-cyclohexyl ester
CAS No.:202270-95-9
Molecular Formula:C₄₃H₅₃O₁₂P
Molecular Weight:792.86
Hs Code.:

[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-dihydroxy-cyclohexyl ester

Synonyms:[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-dihydroxy-cyclohexyl ester

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Chemical Property of [2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-dihydroxy-cyclohexyl ester

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Technology Process of [2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-dihydroxy-cyclohexyl ester

There total 6 articles about [2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-dihydroxy-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 202270-94-8
[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1R,2R,3R,4R,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-bis-(4-methoxy-benzyloxy)-cyclohexyl ester

: 202270-95-9
[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-dihydroxy-cyclohexyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 2h; Ambient temperature;
DOI:10.1021/jo972046p

Reference yield:

: 42890-78-8
(S)-(-)-isopropylidenedioxybutyl bromide

: 202270-95-9
[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-dihydroxy-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaI

2: 96 percent / NaH / dimethylformamide / 0.5 h / Ambient temperature

3: 93 percent / DDQ / CH₂Cl₂; H₂O / 2 h / Ambient temperature

With sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo972046p

Reference yield:

: 67987-67-1,98095-37-5,104596-85-2
(4S)-4-(2-iodoethyl)-2,2-dimethyl-1,3-dioxolane

: 202270-95-9
[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-3-benzyloxy-2,6-bis-benzyloxymethoxy-4,5-dihydroxy-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / NaH / dimethylformamide / 0.5 h / Ambient temperature

2: 93 percent / DDQ / CH₂Cl₂; H₂O / 2 h / Ambient temperature

With sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo972046p