α,α-diphenyl-1-tricyclo[3.3.1.1.(3,7)]decanemethanol

Base Information

• Chemical Name: α,α-diphenyl-1-tricyclo[3.3.1.1.(3,7)]decanemethanol
• CAS No.: 66951-99-3
• Molecular Formula: C₂₃H₂₆O
• Molecular Weight: 318.459
• Mol file: 66951-99-3.mol

Synonyms:α,α-diphenyl-1-tricyclo[3.3.1.1.(3,7)]decanemethanol

Chemical Property of α,α-diphenyl-1-tricyclo[3.3.1.1.(3,7)]decanemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α-diphenyl-1-tricyclo[3.3.1.1.(3,7)]decanemethanol

There total 8 articles about α,α-diphenyl-1-tricyclo[3.3.1.1.(3,7)]decanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

diethyl ether (60-29-7,927820-24-4) + 1-Adamantanecarbonyl chloride (2094-72-6) + phenylmagnesium bromide → ethyl 1-adamantanecarboxylate (2094-73-7) + 1-benzoyladamantane (31919-47-8) + α,α-diphenyl-1-tricyclo[3.3.1.1.(3,7)]decanemethanol (66951-99-3)

Guidance literature:

at 20 ℃; for 48h;

DOI:10.1135/cccc20060709

Reference yield: 47.0%

benzophenone (119-61-9) + 1-Adamantyllithium (3732-30-7) → α,α-diphenyl-1-tricyclo[3.3.1.1.(3,7)]decanemethanol (66951-99-3) + [4-(adamantan-1-yl)phenyl] (phenyl)methanone (69261-68-3)

Guidance literature:

In diethyl ether; pentane; Product distribution; Ambient temperature; various bridgehead organo-lithium compounds with nonenolisable ketons examined in various media; rate of 1-6 and 1-2 addition investigated;

DOI:10.1016/S0040-4020(01)91260-8

Reference yield: 36.0%

1-Adamantyl bromide (768-90-1) + benzophenone (119-61-9) → α,α-diphenyl-1-tricyclo[3.3.1.1.(3,7)]decanemethanol (66951-99-3)

Guidance literature:

With lithium sodium; In diethyl ether; at -25 ℃;

DOI:10.1016/S0040-4039(00)80386-X

upstream raw materials:

1-benzoyladamantane

1-Adamantyl bromide

benzophenone

1-chloroadamantane

Downstream raw materials:

1-[6,6-diphenyl-6-(1-tricyclo[3.3.1.1.3,7]decyl)hexyl]piperidine

4-[6,6-diphenyl-6-(1-tricyclo[3.3.1.1.(3,7)]decyl)hexyl]-1-methylpiperazine

ζ,ζ-diphenyl-ζ-(1-tricyclo[3.3.1.1.(3,7)]decane)hexanol

ethyl ε,ε-diphenyl-ε-(1-tricyclo[3.3.1.1.(3,7)]decane)hexanoate

Refernces

• 1、 Dubois, Jacques-Emile,Bauer, Pierre,Briand, Sylvette. "REDUCTION POTENCIAL OF REAGENTS : II - A TOOL TO ANTICIPATE YIELDS OF ORGANOMETALLIC REACTIONS ?". . p. 3935 - 3936. Retrieved 2007/10/02.