5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carbonitrile

Base Information

Chemical Name:5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carbonitrile
CAS No.:1391108-32-9
Molecular Formula:C₁₉H₁₄ClIN₂
Molecular Weight:432.691
Hs Code.:

Synonyms:5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carbonitrile

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Chemical Property of 5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carbonitrile

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Technology Process of 5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carbonitrile

There total 6 articles about 5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1391108-31-8
5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carboxamide

: 1391108-32-9
5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carbonitrile

Guidance literature:: With pyridine; 2,2-dimethylpropanoic anhydride; In 1,4-dioxane; at 20 ℃; for 3h;
DOI:10.1021/jm4001105

Reference yield:

: 1384513-05-6
ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

: 1391108-32-9
5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 24 h

1.2: 0.08 h

2.1: sodium hydroxide / water; ethanol; 1,4-dioxane / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; ammonia / 1,4-dioxane; dichloromethane / 20 °C

4.1: 2,2-dimethylpropanoic anhydride; pyridine / 1,4-dioxane / 3 h / 20 °C

With pyridine; ammonia; 2,2-dimethylpropanoic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; 1.2: |Paal-Knorr Pyrrole Synthesis;
DOI:10.1021/jm4001105

Reference yield:

: 1384513-06-7
ethyl 5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carboxylate

: 1391108-32-9
5-(4-chlorophenyl)-4-(3-iodophenyl)-1,2-dimethyl-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; ethanol; 1,4-dioxane / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; ammonia / 1,4-dioxane; dichloromethane / 20 °C

3: 2,2-dimethylpropanoic anhydride; pyridine / 1,4-dioxane / 3 h / 20 °C

With pyridine; ammonia; 2,2-dimethylpropanoic anhydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1021/jm4001105