N-[(5R,6R)-5-hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl]-2,6-dimethylbenzenecarboxamide

Base Information

Chemical Name:N-[(5R,6R)-5-hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl]-2,6-dimethylbenzenecarboxamide
CAS No.:827609-26-7
Molecular Formula:C₁₆H₁₇NO₂S
Molecular Weight:287.382
Hs Code.:

Synonyms:N-[(5R,6R)-5-hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl]-2,6-dimethylbenzenecarboxamide

Suppliers and Price of N-[(5R,6R)-5-hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl]-2,6-dimethylbenzenecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(5R,6R)-5-hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl]-2,6-dimethylbenzenecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(5R,6R)-5-hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl]-2,6-dimethylbenzenecarboxamide

There total 8 articles about N-[(5R,6R)-5-hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl]-2,6-dimethylbenzenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 21900-37-8
2,6-dimethylbenzoyl chloride

: 827609-21-2
cis-(5R,6R)-6-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-5-ol

: 827609-26-7
N-[(5R,6R)-5-hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl]-2,6-dimethylbenzenecarboxamide

Guidance literature:: With potassium hydrogencarbonate; In water; at 80 ℃; for 2.5h;
DOI:10.1002/ejoc.200400351

Reference yield:

: 16378-06-6
3-(3-thienyl)propanoic acid

: 827609-26-7
N-[(5R,6R)-5-hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl]-2,6-dimethylbenzenecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 54 percent / phosphorus pentoxide; methanesulfonic acid / 0.67 h / 20 °C

2.1: KOH; iodobenzene diacetate / methanol / 24 h / 20 °C

2.2: 70 percent / HCl / ethanol / 4 h / 20 °C

3.1: 1.35 g / dicyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 8 h / 20 °C

4.1: 80 percent / HCl / methanol / 20 h / 30 °C

5.1: 85 percent / Na₂CO₃; CH₃COOH / methanol / 5 h / pH 4.5 / Heating

6.1: BH₃*THF / tetrahydrofuran / 6 h / Heating

7.1: 76 percent / potassium hydrogen carbonate; IPAC / H₂O / 2.5 h / 80 °C

With hydrogenchloride; dmap; phosphorus pentaoxide; potassium hydroxide; borane-THF; methanesulfonic acid; [bis(acetoxy)iodo]benzene; sodium carbonate; potassium hydrogencarbonate; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/ejoc.200400351

Reference yield:

: 5650-52-2
4,5-dihydro-6H-cyclopenta[b]thiophen-6-one

: 827609-26-7
N-[(5R,6R)-5-hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl]-2,6-dimethylbenzenecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: KOH; iodobenzene diacetate / methanol / 24 h / 20 °C

1.2: 70 percent / HCl / ethanol / 4 h / 20 °C

2.1: 1.35 g / dicyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 8 h / 20 °C

3.1: 80 percent / HCl / methanol / 20 h / 30 °C

4.1: 85 percent / Na₂CO₃; CH₃COOH / methanol / 5 h / pH 4.5 / Heating

5.1: BH₃*THF / tetrahydrofuran / 6 h / Heating

6.1: 76 percent / potassium hydrogen carbonate; IPAC / H₂O / 2.5 h / 80 °C

With hydrogenchloride; dmap; potassium hydroxide; borane-THF; [bis(acetoxy)iodo]benzene; sodium carbonate; potassium hydrogencarbonate; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/ejoc.200400351