tert-butyl 4-{[3-(4-fluorophenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{[3-(4-fluorophenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate
CAS No.:1356861-99-8
Molecular Formula:C₂₂H₃₃FN₂O₃
Molecular Weight:392.514
Hs Code.:

Synonyms:tert-butyl 4-{[3-(4-fluorophenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{[3-(4-fluorophenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-{[3-(4-fluorophenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-{[3-(4-fluorophenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356861-94-3
2-chloro-N-[3-(4-fluorophenyl)pentan-3-yl]acetamide

: 1356861-99-8
tert-butyl 4-{[3-(4-fluorophenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; thiourea / ethanol / 16 h / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 72 h / 20 °C / Cooling with ice

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; thiourea; In ethanol; acetonitrile;
DOI:10.1248/cpb.59.1376

Reference yield:

: 403-33-8
methyl 4-flurobenzoate

: 1356861-99-8
tert-butyl 4-{[3-(4-fluorophenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran; diethyl ether / 2 h / -20 - 0 °C

2: sulfuric acid / acetic acid / 4 h / 20 °C / Cooling with ice

3: acetic acid; thiourea / ethanol / 16 h / Reflux

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 72 h / 20 °C / Cooling with ice

With sulfuric acid; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; thiourea; In tetrahydrofuran; diethyl ether; ethanol; acetic acid; acetonitrile; 2: Ritter reaction;
DOI:10.1248/cpb.59.1376

Reference yield:

: 76481-34-0
3-(4'-fluorophenyl)pentan-3-ol

: 1356861-99-8
tert-butyl 4-{[3-(4-fluorophenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / acetic acid / 4 h / 20 °C / Cooling with ice

2: acetic acid; thiourea / ethanol / 16 h / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 72 h / 20 °C / Cooling with ice

With sulfuric acid; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; thiourea; In ethanol; acetic acid; acetonitrile; 1: Ritter reaction;
DOI:10.1248/cpb.59.1376