76481-34-0

Basic information

• Product Name: 3-(4'-fluorophenyl)pentan-3-ol
• Synonyms: 3-(4'-fluorophenyl)pentan-3-ol
• CAS NO: 76481-34-0
• Molecular Weight: 182.238
• Mol File: 76481-34-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-(4'-fluorophenyl)pentan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4'-fluorophenyl)pentan-3-ol(76481-34-0)
• EPA Substance Registry System: 3-(4'-fluorophenyl)pentan-3-ol(76481-34-0)

Safety Data

• Hazardous Substances Data: 76481-34-0(Hazardous Substances Data)

Upstream product

• 1493-23-8 (4-fluorophenyl)lithium 
• 96-22-0 pentan-3-one 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 925-90-6 ethylmagnesium bromide 
• 403-33-8 methyl 4-flurobenzoate 
• 352-13-6 4-flourophenylmagnesium bromide 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 540-36-3 para-difluorobenzene 

Downstream Products

• 1186337-19-8 C₂₀H₂₅FO 
• 1186337-18-7 C₁₇H₁₉FO 
• 1356861-94-3 2-chloro-N-[3-(4-fluorophenyl)pentan-3-yl]acetamide 
• 1356861-80-7 N-[3-(4-fluorophenyl)pentan-3-yl]-1-(2-phenylethyl)-piperidine-4-carboxamide 
• 1356861-81-8 N-[3-(4-fluorophenyl)pentan-3-yl]-1-(2-phenylethyl)piperidine-4-carboxamide fumarate 
• 1356861-99-8 tert-butyl 4-{[3-(4-fluorophenyl)pentan-3-yl]carbamoyl}piperidine-1-carboxylate 
• 1356862-00-4 N-[3-(4-fluorophenyl)pentan-3-yl]piperidine-4-carboxamide hydrochloride 
• 306761-58-0 3-(4-fluorophenyl)pentan-3-amine 
• 737801-50-2 3-[1-ethyl-1-(4-fluoro-phenyl)-propyl]-5-methoxy-1H-indole 
• 737801-36-4 N-{3-[1-ethyl-1-(4-fluoro-phenyl)-propyl]-1H-indol-7-yl}-N-methyl-methanesulfonamide 
• 737801-34-2 N-[3-(1-ethyl-1-phenyl-propyl)-1H-indol-7-yl]-acetamide 
• 737801-49-9 3-[1-ethyl-1-(4-fluoro-phenyl)-propyl]-5-fluoro-1H-indole 
• 737801-48-8 3-[1-ethyl-1-(4-fluoro-phenyl)-propyl]-1H-indole 
• 128270-98-4 2-<4'-(trifluoromethyl)phenyl>-2-(4''-nitrophenyl)-3-ethyl-3-(4'''-fluorophenyl)pentane 

Relevant articles and documents

Triphosgene and DMAP as Mild Reagents for Chemoselective Dehydration of Tertiary Alcohols

The utility of triphosgene and DMAP as mild reagents for chemoselective dehydration of tertiary alcohols is reported. Performed in dichloromethane at room temperature, this reaction is readily tolerated by a broad scope of substrates, yielding alkenes preferentially with the (E)-geometry. While formation of the Hofmann products is generally favored, a dramatic change in alkene selectivity toward the Zaitzev products is observed when the reaction is carried out in dichloroethane at reflux.

Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors

Based on our hypothesis that the 3,3-diphenylpentane (DPP) skeleton is useful as a multi-template for creation of various biologically active compounds and acts as a steroid skeleton substitute, we designed and synthesized novel HMG-CoA reductase inhibitors with a DPP skeleton. Among them, sodium (E,3R,5S)-7-(2-(4-fluorophenyl)-4-(3-phenylpentan-3-yl)phenyl)-3,5-dihydroxy-hept-6-enoate showed potent HMG-CoA reductase-inhibitory activity comparable with that of clinically useful mevastatin.

INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.