2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester

Base Information

Chemical Name:2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester
CAS No.:219638-16-1
Molecular Formula:C₂₂H₂₆N₂O₆
Molecular Weight:414.458
Hs Code.:

Synonyms:2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester

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Chemical Property of 2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester

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Technology Process of 2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester

There total 1 articles about 2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 127590-90-3
3-(benzyloxy)-6-(chloromethyl)pyridine

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 219638-16-1
2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.06.048

Reference yield: 90.0%

: 219638-16-1
2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester

: 219638-17-2
2-amino-3-(5-benzyloxy-pyridin-2-yl)-propionic acid

Guidance literature:: With sulfuric acid;
DOI:10.1016/j.bmcl.2005.06.048

Reference yield:

: 219638-16-1
2-acetylamino-2-(5-benzyloxy-pyridin-2-ylmethyl)-malonic acid diethyl ester

: [1-allylcarbamoyl-2-(5-benzyloxy-pyridin-2-yl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / aq. H₂SO₄

2: 99 percent / aq. Na₂CO₃ / tetrahydrofuran

3: CDI / CH₂Cl₂

With sulfuric acid; sodium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.06.048