5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole

Base Information

• Chemical Name: 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole
• CAS No.: 143722-28-5
• Molecular Formula: C₃₄H₂₈N₄O₃S
• Molecular Weight: 572.687
• Mol file: 143722-28-5.mol

Synonyms:5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole

Chemical Property of 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole

There total 11 articles about 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + 2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol (135050-95-2) → 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole (143722-28-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1002/jlcr.2580340303

Reference yield:

4-bromobenzenemethanol (873-75-6) → 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole (143722-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: nitrogen / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / toluene

2: potassium carbonate / N,N-dimethyl acetamide

With nitrogen; potassium carbonate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In N,N-dimethyl acetamide; toluene;

Reference yield:

2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)-phenylboronic acid (143722-25-2) → 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole (143722-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: nitrogen / tetrakis(triphenylphosphine)palladium ⁽⁰⁾ / toluene

2: potassium carbonate / N,N-dimethyl acetamide

With nitrogen; potassium carbonate; tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In N,N-dimethyl acetamide; toluene;

upstream raw materials:

methanesulfonyl chloride

2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol

4-iodobenzoic acid

1.4-dibromobenzene

Downstream raw materials:

2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

2-Propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-[2-(2,2,2-trifluoro-acetyl)-pyrrol-1-yl]-3H-imidazole-4-carboxylic acid ethyl ester

CI 996

2-Propyl-5-[2-(2,2,2-trifluoro-acetyl)-pyrrol-1-yl]-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester