135050-95-2

Basic information

• Product Name: 2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol
• Synonyms: 2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol
• CAS NO: 135050-95-2
• Molecular Weight: 494.596
• Mol File: 135050-95-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol(135050-95-2)
• EPA Substance Registry System: 2'-<2-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-methanol(135050-95-2)

Safety Data

• Hazardous Substances Data: 135050-95-2(Hazardous Substances Data)

Upstream product

• 15290-29-6 4-(trimethylsilyl)benzoic acid 
• 138804-35-0 2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1-biphenyl-4-carboxaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 143722-25-2 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)-phenylboronic acid 
• 160514-13-6 2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-methanol 
• 76-83-5 trityl chloride 
• 1711-02-0 4-iodobenzoic acid chloride 
• 6999-03-7 1-bromo-4-(trimethylsilyl)benzene 
• 18282-51-4 4-iodo-benzyl alcohol 
• 106-37-6 1.4-dibromobenzene 
• 619-58-9 4-iodobenzoic acid 
• 157756-27-9 5-<4'-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl><1,1'-biphenyl>-2-yl>-2-(triphenylmethyl)-1H-tetrazole 

Downstream Products

• 143722-28-5 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole 
• 138804-35-0 2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1-biphenyl-4-carboxaldehyde 
• 172875-59-1 ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate 
• 1026262-77-0 2-Propyl-5-[2-(2,2,2-trifluoro-acetyl)-pyrrol-1-yl]-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester 
• 1027968-99-5 2-Propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-[2-(2,2,2-trifluoro-acetyl)-pyrrol-1-yl]-3H-imidazole-4-carboxylic acid ethyl ester 
• 150438-02-1 CI 996 

Relevant articles and documents

Preparation method of olmesartan medoxomil

The invention discloses a preparation method of olmesartan medoxomil. The preparation method comprises the following steps of using 4-bromobenzaldehyde as a starting raw material, performing Suzuki coupling reaction with 2-(2'-triphenylmethyl tetrazole-5-yl)borophenylic acid (III), and reducing by NaBH4 (sodium borohydride), so as to obtain an olmesartan medoxomil intermediate of N-triphenylmethyl-5-(4'-hydroxymethyl biphenyl-2-yl)tetrazole (IV); directly reacting the intermediate (IV) and 2-propyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylic acid ethyl ester, so as to obtain a compound VI; performing hydrolysis, esterification and deprotection, so as to obtain the olmesartan medoxomil. Compared with the prior art, the preparation method has the advantages that the obtaining of raw materials is easy, the amount of byproducts is fewer, the reaction line is shortened, the reaction condition is mild, the operation is simple, the total yield of product is improved, and the preparation method is suitable for industrialized production.

PROCESS FOR PREPARING BIPHENYLTETRAZOLE COMPOUNDS

Method for the preparing biphenyltetrazole compounds which are angiotensin II receptor antagonists or which are useful intermediates to prepare angiotensin II receptor antagonists. An illustrative biphenyl tetrazole compound is 2-n-butyl-4-chloro-1-[(2'-(tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imi dazole-5-methanol, potassium salt.