3a,6a-bis-(4-tert-butyl-phenyl)-1,6-bis-(4-methoxy-benzyl)-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione

Base Information

• Chemical Name: 3a,6a-bis-(4-tert-butyl-phenyl)-1,6-bis-(4-methoxy-benzyl)-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione
• CAS No.: 385818-23-5
• Molecular Formula: C₄₀H₄₆N₄O₄
• Molecular Weight: 646.83
• Mol file: 385818-23-5.mol

Synonyms:3a,6a-bis-(4-tert-butyl-phenyl)-1,6-bis-(4-methoxy-benzyl)-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione

Chemical Property of 3a,6a-bis-(4-tert-butyl-phenyl)-1,6-bis-(4-methoxy-benzyl)-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3a,6a-bis-(4-tert-butyl-phenyl)-1,6-bis-(4-methoxy-benzyl)-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione

There total 1 articles about 3a,6a-bis-(4-tert-butyl-phenyl)-1,6-bis-(4-methoxy-benzyl)-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

p-methoxybenzylurea (54582-35-3) + 4,4'-di-tert-butylbenzil (76471-78-8) → 3a,6a-bis-(4-tert-butyl-phenyl)-1,6-bis-(4-methoxy-benzyl)-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione (385818-23-5)

Guidance literature:

With trifluoroacetic acid; In benzene; for 24h; Heating;

DOI:10.1021/ja011651d

Reference yield: 55.0%

methyl 3-bromo-2-(bromomethyl)propionate (22262-60-8) + 3a,6a-bis-(4-tert-butyl-phenyl)-1,6-bis-(4-methoxy-benzyl)-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione (385818-23-5) → 2a,7b-bis-(4-tert-butyl-phenyl)-2,3-bis-(4-methoxy-benzyl)-1,4-dioxo-octahydro-2,3,4a,7a-tetraaza-cyclopenta[cd]indene-6-carboxylic acid methyl ester

Guidance literature:

With CsCO₃; In acetonitrile; for 20h; Heating;

DOI:10.1021/ja011651d

Reference yield:

3a,6a-bis-(4-tert-butyl-phenyl)-1,6-bis-(4-methoxy-benzyl)-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione (385818-23-5) → 2a,7b-bis-(4-tert-butyl-phenyl)-1,4-dioxo-octahydro-2,3,4a,7a-tetraaza-cyclopenta[cd]indene-6-carboxylic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / CsCO₃ / acetonitrile / 20 h / Heating

2: 61 percent / ammonium cerium (IV) nitrate / acetonitrile; H₂O / 24 h / 20 °C

3: 99 percent / LiI*3H₂O; 2,6-lutidine / 30 h / Heating

With 2,6-dimethylpyridine; ammonium cerium(IV) nitrate; lithium iodide; In water; acetonitrile;

DOI:10.1021/ja011651d

upstream raw materials:

p-methoxybenzylurea

4,4'-di-tert-butylbenzil