54582-35-3

Basic information

• Product Name: N-(4-METHOXYBENZYL)UREA
• Synonyms: N-(4-METHOXYBENZYL)UREA;1-(4-methoxybenzyl)urea
• CAS NO: 54582-35-3
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 180.2
• Mol File: 54582-35-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 160-162°
• Boiling Point: 327.9°C at 760 mmHg
• Flash Point: 152.1°C
• Appearance: /
• Density: 1.156g/cm³
• Vapor Pressure: 0.000196mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.63±0.46(Predicted)
• CAS DataBase Reference: N-(4-METHOXYBENZYL)UREA(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-METHOXYBENZYL)UREA(54582-35-3)
• EPA Substance Registry System: N-(4-METHOXYBENZYL)UREA(54582-35-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 54582-35-3(Hazardous Substances Data)

Usage

General Description

N-(4-Methoxybenzyl)urea is a chemical compound with the molecular formula C9H12N2O2. It is a urea derivative with a substituted benzyl group containing a methoxy (CH3O) functional group. N-(4-METHOXYBENZYL)UREA has been studied for its potential pharmaceutical applications, including its use as a smooth muscle relaxant and in the treatment of central nervous system disorders. It is also used in organic synthesis as a building block for creating more complex chemical structures. N-(4-Methoxybenzyl)urea has shown promise in various research areas and continues to be investigated for its potential therapeutic and synthetic applications.

InChI:InChI=1/C9H12N2O2/c1-13-8-4-2-7(3-5-8)6-11-9(10)12/h2-5H,6H2,1H3,(H3,10,11,12)

Upstream product

• 61642-86-2 S-phenyl thiocarbamate 
• 2393-23-9 4-methoxy-benzylamine 
• 95062-72-9 S-(4-methylphenyl) thiocarbamate 
• 95062-74-1 S-(4-chlorophenyl) thiocarbamate 
• 95062-75-2 S-(4-bromophenyl) thiocarbamate 
• 590-28-3 potassium cyanate 
• 74295-89-9 N-(p-Methoxybenzyl)cyanamide 
• 57-13-6 urea 
• 123-11-5 4-methoxy-benzaldehyde 
• 556-89-8 nitrourea 
• 17061-61-9 4-methoxybenzylamine hydrochloride 

Downstream Products

• 104375-82-8 N-nitroso-N-(p-methoxybenzyl)urea 
• 190435-92-8 1,6-bis(p-methoxybenzyl)-7,8-di-p-tolylglycoluril 
• 190435-93-9 [6-Ethoxycarbonylmethyl-3,4-bis-(4-methoxy-benzyl)-2,5-dioxo-3a,6a-di-p-tolyl-hexahydro-imidazo[4,5-d]imidazol-1-yl]-acetic acid ethyl ester 
• 54052-74-3 6-amino-1-(4-methoxy-benzyl)-1H-pyrimidine-2,4-dione 
• 158893-32-4 C₁₂H₁₃N₃O₃ 
• 1616091-89-4 C₁₃H₁₇N₃O₄S 
• 74370-35-7 3-(4-methoxybenzyl)-6-methylsulfanyl-1H-[1,3,5]triazine-2,4-dione 
• 1616091-96-3 C₁₁H₁₁N₃O₃S 
• 1616091-75-8 (2-(1-(4-iodobenzyl)-5-(4-methoxybenzyl)-1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazin-2-ylamino)ethyl)guanidine 
• 1616091-73-6 (2-(1-(4-(trifluoromethyl)benzyl)-5-(4-methoxybenzyl)-1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazin-2-ylamino)ethyl)guanidine 
• 1616091-72-5 (2-(1-(4-chlorobenzyl)-5-(4-methoxybenzyl)-1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazin-2-ylamino)ethyl)guanidine 
• 1616091-71-4 (2-(1-(4-fluorobenzyl)-5-(4-methoxybenzyl)-1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazin-2-ylamino)ethyl)guanidine 
• 1616091-70-3 (2-(1-(4-methylbenzyl)-5-(4-methoxybenzyl)-1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazin-2-ylamino)ethyl)guanidine 

Relevant articles and documents

Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation

Monosubstituted ureas are important scaffolds in organic chemistry. They appear in various biologically active compounds and serve as versatile precursors in synthesis. Monosubstituted ureas were originally prepared using toxic and hazardous phosgene equivalents. Modern methods include transamidation of urea and nucleophilic addition to cyanate salts, both of which suffer from a narrow substrate scope due to the need for a strong acid and prolonged reaction times. We hereby report that ammonium chloride can promote the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeds rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it is compatible with other nucleophiles, acid-labile moieties, and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatography.

MONOSUBSTITUTED UREA DERIVATIVES AS A SELF-TANNING SUBSTANCE

The present invention relates to the use of monosubstiuted urea derivatives of the formula I as self-tanning substance, for increasing melanin synthesis, for improving melanin transport and/or improving the distribution of melanin in suprabasal layers, and to preparations comprising these urea derivatives.

Carboxylic acid-catalyzed one-pot synthesis of cyanoacetylureas and their cyclization to 6-aminouracils in guanidine ionic liquid

A novel, one-pot, carboxylic acid-catalyzed synthesis of cyanoacetylureas via in situ generated ureas and their cyclization to 6-aminouracils in the presence of the guanidine-based ionic liquid 1,1,3,3-tetramethylguanidine lactate [TMG][Lac] is described. The ureas were synthesized from amines and potassium cyanate, which on reaction with cyanoacetic acid in the presence of acetic anhydride in the same pot afforded cyanoacetylureas, which undergo cyclization in [TMG][Lac] as solvent as well as catalyst to afford 6-aminouracils. One-pot synthesis of cyanoacetylureas, efficient and rapid cyclization, better yield, shorter reaction time, easy workup procedure, and recyclability of the ionic liquid are some advantages of this procedure.