1-benzyl-4-(4-methoxyphenyl)-5-[(4-methoxyphenyl)ethynyl]-1H-1,2,3-triazole

Base Information

• Chemical Name: 1-benzyl-4-(4-methoxyphenyl)-5-[(4-methoxyphenyl)ethynyl]-1H-1,2,3-triazole
• CAS No.: 1414870-95-3
• Molecular Formula: C₂₅H₂₁N₃O₂
• Molecular Weight: 395.461
• Mol file: 1414870-95-3.mol

Synonyms:1-benzyl-4-(4-methoxyphenyl)-5-[(4-methoxyphenyl)ethynyl]-1H-1,2,3-triazole

Chemical Property of 1-benzyl-4-(4-methoxyphenyl)-5-[(4-methoxyphenyl)ethynyl]-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 1-benzyl-4-(4-methoxyphenyl)-5-[(4-methoxyphenyl)ethynyl]-1H-1,2,3-triazole

There total 4 articles about 1-benzyl-4-(4-methoxyphenyl)-5-[(4-methoxyphenyl)ethynyl]-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-bromo-2-(4-methoxyphenyl)acetylene (33675-41-1) + benzyl azide (622-79-7) + 4-methoxyphenylacetylen (768-60-5) → 1-benzyl-4-(4-methoxyphenyl)-5-[(4-methoxyphenyl)ethynyl]-1H-1,2,3-triazole (1414870-95-3)

Guidance literature:

With lithium tert-butoxide; In 1,2-dichloro-ethane; at 25 ℃; for 12h; regioselective reaction; Schlenk technique; Molecular sieve; Inert atmosphere;

DOI:10.1002/aoc.5319

Reference yield: 81.0%

benzyl bromide (100-39-0) + 4-methoxyphenylacetylen (768-60-5) → 1-benzyl-4-(4-methoxyphenyl)-5-[(4-methoxyphenyl)ethynyl]-1H-1,2,3-triazole (1414870-95-3)

Guidance literature:

With copper(I) oxide; sodium azide; In methanol; at 20 ℃; for 12h;

DOI:10.1055/s-0031-1290445

Reference yield: 71.0%

benzyl azide (622-79-7) + 4-methoxyphenylacetylen (768-60-5) → 1-benzyl-4-(4-methoxyphenyl)-5-[(4-methoxyphenyl)ethynyl]-1H-1,2,3-triazole (1414870-95-3)

Guidance literature:

With potassium hydroxide; copper(I) bromide; In ethanol; at 60 ℃; for 20h;

DOI:10.1016/j.tet.2013.09.093

upstream raw materials:

benzyl bromide

4-methoxyphenylacetylen

benzyl azide

1-bromo-2-(4-methoxyphenyl)acetylene