(1R,2R)-(7,7-dimethyl-2-exo-benzylselenylbicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester

Base Information

• Chemical Name: (1R,2R)-(7,7-dimethyl-2-exo-benzylselenylbicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester
• CAS No.: 247078-55-3
• Molecular Formula: C₂₃H₂₈O₃SSe
• Molecular Weight: 463.5
• Mol file: 247078-55-3.mol

Synonyms:(1R,2R)-(7,7-dimethyl-2-exo-benzylselenylbicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester

Chemical Property of (1R,2R)-(7,7-dimethyl-2-exo-benzylselenylbicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-(7,7-dimethyl-2-exo-benzylselenylbicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester

There total 3 articles about (1R,2R)-(7,7-dimethyl-2-exo-benzylselenylbicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

benzyl selenol (16645-12-8) + (1S)-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester (108885-08-1) → (1R,2R)-(7,7-dimethyl-2-exo-benzylselenylbicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester (247078-55-3)

Guidance literature:

benzyl selenol; (1S)-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester; With boron trifluoride; In dichloromethane; at 20 ℃; for 1h;

With triethylsilane; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1016/S0040-4020(99)00507-4

Reference yield:

Camphorsulfonyl chloride (21286-54-4) → (1R,2R)-(7,7-dimethyl-2-exo-benzylselenylbicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester (247078-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 76 percent / Py / 2 h / 0 °C

2.1: BF₃*H₂O / CH₂Cl₂ / 1 h / 20 °C

2.2: 20 percent / Et₃SiH / CH₂Cl₂ / 72 h / 20 °C

With pyridine; boron trifluoride; In dichloromethane; 1.1: Substitution / 2.1: Addition / 2.2: Reduction;

DOI:10.1016/S0040-4020(99)00507-4

Reference yield:

phenol (108-95-2,27073-41-2) → (1R,2R)-(7,7-dimethyl-2-exo-benzylselenylbicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester (247078-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 76 percent / Py / 2 h / 0 °C

2.1: BF₃*H₂O / CH₂Cl₂ / 1 h / 20 °C

2.2: 20 percent / Et₃SiH / CH₂Cl₂ / 72 h / 20 °C

With pyridine; boron trifluoride; In dichloromethane; 1.1: Substitution / 2.1: Addition / 2.2: Reduction;

DOI:10.1016/S0040-4020(99)00507-4

upstream raw materials:

benzyl selenol

(1S)-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methane sulfonic acid phenyl ester

Camphorsulfonyl chloride

phenol