2-methyl-4-methoxy-N-(4-benzyloxy-3-methoxyphenethyl)-5-benzyloxyphenylacetamide

Base Information

Chemical Name:2-methyl-4-methoxy-N-(4-benzyloxy-3-methoxyphenethyl)-5-benzyloxyphenylacetamide
CAS No.:97400-60-7
Molecular Formula:C₃₃H₃₅NO₅
Molecular Weight:525.645
Hs Code.:

Synonyms:2-methyl-4-methoxy-N-(4-benzyloxy-3-methoxyphenethyl)-5-benzyloxyphenylacetamide

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Chemical Property of 2-methyl-4-methoxy-N-(4-benzyloxy-3-methoxyphenethyl)-5-benzyloxyphenylacetamide

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Technology Process of 2-methyl-4-methoxy-N-(4-benzyloxy-3-methoxyphenethyl)-5-benzyloxyphenylacetamide

There total 13 articles about 2-methyl-4-methoxy-N-(4-benzyloxy-3-methoxyphenethyl)-5-benzyloxyphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 22231-61-4
2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine

: 60699-62-9
2-methyl-4-methoxy-5-benzyloxyphenylacetic acid

: 97400-60-7
2-methyl-4-methoxy-N-(4-benzyloxy-3-methoxyphenethyl)-5-benzyloxyphenylacetamide

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/S0031-9422(00)80749-9

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 97400-60-7
2-methyl-4-methoxy-N-(4-benzyloxy-3-methoxyphenethyl)-5-benzyloxyphenylacetamide

Guidance literature:: Multi-step reaction with 9 steps

1: NaOH

2: POCl₃

3: conc.H₂SO₄ / 17 h / 65 - 75 °C / demethylation

4: K₂CO₃

5: NaBH₄ / propan-2-ol

6: PBr₃ / diethyl ether

7: dimethylformamide

8: KOH / aq. ethanol / Heating

9: 60 percent / N,N'-dicyclohexylcarbodiimide / CH₂Cl₂

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; sulfuric acid; phosphorus tribromide; potassium carbonate; dicyclohexyl-carbodiimide; trichlorophosphate; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/S0031-9422(00)80749-9

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 97400-60-7
2-methyl-4-methoxy-N-(4-benzyloxy-3-methoxyphenethyl)-5-benzyloxyphenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄

2: PBr₃ / diethyl ether

3: dimethylformamide

4: LiAlH₄ / diethyl ether

5: 60 percent / N,N'-dicyclohexylcarbodiimide / CH₂Cl₂

With sodium tetrahydroborate; lithium aluminium tetrahydride; phosphorus tribromide; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0031-9422(00)80749-9