2-Methoxy-1-((S)-2-trifluoromethyl-benzenesulfinyl)-piperidine

Base Information

• Chemical Name: 2-Methoxy-1-((S)-2-trifluoromethyl-benzenesulfinyl)-piperidine
• CAS No.: 863211-88-5
• Molecular Formula: C₁₃H₁₆F₃NO₂S
• Molecular Weight: 307.337
• Mol file: 863211-88-5.mol

Synonyms:2-Methoxy-1-((S)-2-trifluoromethyl-benzenesulfinyl)-piperidine

Chemical Property of 2-Methoxy-1-((S)-2-trifluoromethyl-benzenesulfinyl)-piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methoxy-1-((S)-2-trifluoromethyl-benzenesulfinyl)-piperidine

There total 3 articles about 2-Methoxy-1-((S)-2-trifluoromethyl-benzenesulfinyl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-((S)-2-Trifluoromethyl-benzenesulfinyl)-piperidine (863211-82-9) + methanol (67-56-1) → 2-trifluoromethyl-benzenesulfinic acid methyl ester + 2-Methoxy-1-((S)-2-trifluoromethyl-benzenesulfinyl)-piperidine (863211-88-5)

Guidance literature:

With N,N,N,N-tetraethylammonium tetrafluoroborate; potassium hydrogencarbonate; at 0 ℃; Electrochemical reaction;

DOI:10.1016/j.tetlet.2005.05.123

Reference yield:

2-trifluoromethyl-benzenesulfinic acid 2-isopropyl-5-methyl-cyclohexyl ester → 2-Methoxy-1-((S)-2-trifluoromethyl-benzenesulfinyl)-piperidine (863211-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methylmagnesium bromide / tetrahydrofuran / 0 °C

1.2: 87 percent / tetrahydrofuran

2.1: 71 percent / Et₄NBF₄; KHCO₃ / 0 °C / Electrochemical reaction

With methylmagnesium bromide; N,N,N,N-tetraethylammonium tetrafluoroborate; potassium hydrogencarbonate; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2005.05.123

Reference yield:

piperidine (110-89-4) → 2-Methoxy-1-((S)-2-trifluoromethyl-benzenesulfinyl)-piperidine (863211-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methylmagnesium bromide / tetrahydrofuran / 0 °C

1.2: 87 percent / tetrahydrofuran

2.1: 71 percent / Et₄NBF₄; KHCO₃ / 0 °C / Electrochemical reaction

With methylmagnesium bromide; N,N,N,N-tetraethylammonium tetrafluoroborate; potassium hydrogencarbonate; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2005.05.123

upstream raw materials:

1-((S)-2-Trifluoromethyl-benzenesulfinyl)-piperidine

methanol

piperidine

Downstream raw materials:

1-[(S)-1-((S)-2-Trifluoromethyl-benzenesulfinyl)-piperidin-2-yl]-propan-2-one

(S)-2-pent-1-ynyl-1-((S)-2-trifluoromethylbenzenesulfinyl)piperidine