1-Naphthalenepropanol,2-(acetyloxy)-a-ethenyldecahydro-a,2,5,5,8a-pentamethyl-,acetate,(aR,1R,2R,4aS,8aS)- (9CI)

Base Information

• Chemical Name: 1-Naphthalenepropanol,2-(acetyloxy)-a-ethenyldecahydro-a,2,5,5,8a-pentamethyl-,acetate,(aR,1R,2R,4aS,8aS)- (9CI)
• CAS No.: 54274-72-5
• Molecular Formula: C₂₄H₄₀O₄
• Molecular Weight: 392.579
• Mol file: 54274-72-5.mol

Synonyms:(R)-5-((1R,2R,4aS,8aS)-2-acetoxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)-3-methylpent-1-en-3-yl acetate

Chemical Property of 1-Naphthalenepropanol,2-(acetyloxy)-a-ethenyldecahydro-a,2,5,5,8a-pentamethyl-,acetate,(aR,1R,2R,4aS,8aS)- (9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

SclareolDiacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sclareol Diacetate is an intermediate in the synthesis of (E)-Labd-13-ene-8,15-diol compounds with antiviral and anticancer activities and has been the most effective growth inhibitor of murine leukemia cell lines P388.

Technology Process of 1-Naphthalenepropanol,2-(acetyloxy)-a-ethenyldecahydro-a,2,5,5,8a-pentamethyl-,acetate,(aR,1R,2R,4aS,8aS)- (9CI)

There total 4 articles about 1-Naphthalenepropanol,2-(acetyloxy)-a-ethenyldecahydro-a,2,5,5,8a-pentamethyl-,acetate,(aR,1R,2R,4aS,8aS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

sclareol (515-03-7) + acetyl chloride (75-36-5) → (R)-5-((1R,2R,4aS,8aS)-2-acetoxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)-3-methylpent-1-en-3-yl acetate (54274-72-5)

Guidance literature:

With N,N-dimethyl-aniline; at 25 ℃; for 12h;

DOI:10.1016/0040-4039(94)88171-5

Reference yield: 54.0%

sclareol (515-03-7) + acetyl chloride (75-36-5) → 8α-acetoxy-13R-hydroxy-labda-14-ene (22628-62-2) + (R)-5-((1R,2R,4aS,8aS)-2-acetoxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)-3-methylpent-1-en-3-yl acetate (54274-72-5)

Guidance literature:

With N,N-dimethyl-aniline;

DOI:10.1016/S0040-4039(00)61456-9

Reference yield:

sclareol (515-03-7) + acetic anhydride (108-24-7) → (R)-5-((1R,2R,4aS,8aS)-2-acetoxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)-3-methylpent-1-en-3-yl acetate (54274-72-5)

Guidance literature:

With pyridine;

upstream raw materials:

sclareol

acetic anhydride

acetyl chloride

Downstream raw materials:

cis-abienol

ent-8α-hydroxy-labda-13(16),14-dien

(12Z)-8α-12,14-labdadien-8-ol

4-Methoxymethoxy-3-[(E)-3-methyl-5-((4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)-pent-2-enyl]-benzaldehyde