(6-METHYL-2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE

Base Information

• Chemical Name: (6-METHYL-2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE
• CAS No.: 885272-76-4
• Molecular Formula: C₁₆H₁₃N₃
• Molecular Weight: 247.299
• Hs Code.: 2933990090
• Mol file: 885272-76-4.mol

Synonyms:(6-METHYL-2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE

Chemical Property of (6-METHYL-2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE

Chemical Property:

• PSA: 41.09000
• LogP: 3.37578

Purity/Quality:

97% ^*data from raw suppliers

(6-Methyl-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-acetonitrile 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-METHYL-2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE

There total 9 articles about (6-METHYL-2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-methyl-2-phenylimidazo[1,2-a]pyridine (1019-89-2) + cyanomethyl bromide (590-17-0) → 2-(6-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)acetonitrile (885272-76-4)

Guidance literature:

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); sodium hydrogencarbonate; In dimethyl sulfoxide; at 20 ℃; for 12h; regioselective reaction; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1021/acs.joc.7b00750

Reference yield: 86.0%

→ 2-(6-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)acetonitrile (885272-76-4)

Guidance literature:

With tris[2-phenylpyridinato-C²,N]iridium(III); sodium hydrogencarbonate; In dimethyl sulfoxide; at 20 ℃; for 12h; Inert atmosphere; Microwave irradiation;

Reference yield: 85.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) + α-bromoacetophenone (70-11-1) + cyanomethyl bromide (590-17-0) → 2-(6-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)acetonitrile (885272-76-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Irradiation; Sealed tube; Inert atmosphere;

DOI:10.1055/a-1704-4822

upstream raw materials:

potassium cyanide

N,N-dimethyl-1-(6-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)methanamine

6-methyl-2-phenylimidazo[1,2-a]pyridine

acetonitrile

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