methyl (2R,S)-2-(N-benzyl-2-bromoethanamido)-3-(tert-butyldimethylsiloxy)propanoate

Base Information

Chemical Name:methyl (2R,S)-2-(N-benzyl-2-bromoethanamido)-3-(tert-butyldimethylsiloxy)propanoate
CAS No.:178100-19-1
Molecular Formula:C₁₉H₃₀BrNO₄Si
Molecular Weight:444.441
Hs Code.:

Synonyms:methyl (2R,S)-2-(N-benzyl-2-bromoethanamido)-3-(tert-butyldimethylsiloxy)propanoate

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Chemical Property of methyl (2R,S)-2-(N-benzyl-2-bromoethanamido)-3-(tert-butyldimethylsiloxy)propanoate

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Technology Process of methyl (2R,S)-2-(N-benzyl-2-bromoethanamido)-3-(tert-butyldimethylsiloxy)propanoate

There total 3 articles about methyl (2R,S)-2-(N-benzyl-2-bromoethanamido)-3-(tert-butyldimethylsiloxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 598-21-0
2-Bromoacetyl bromide

: 160848-03-3
methyl (2R,S)-2-(N-benzylamino)-3-(tert-butyldimethylsiloxy)propanoate

: 178100-19-1
methyl (2R,S)-2-(N-benzyl-2-bromoethanamido)-3-(tert-butyldimethylsiloxy)propanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/0040-4020(96)00288-8

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 178100-19-1
methyl (2R,S)-2-(N-benzyl-2-bromoethanamido)-3-(tert-butyldimethylsiloxy)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / 4-dimethylaminopyridine, Et₃N / CH₂Cl₂ / Ambient temperature

2: 89 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With dmap; triethylamine; In dichloromethane;
DOI:10.1016/0040-4020(96)00288-8

Reference yield:

: 144001-42-3
methyl 2-(benzylamino)-3-hydroxypropanoate

: 178100-19-1
methyl (2R,S)-2-(N-benzyl-2-bromoethanamido)-3-(tert-butyldimethylsiloxy)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / 4-dimethylaminopyridine, Et₃N / CH₂Cl₂ / Ambient temperature

2: 89 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With dmap; triethylamine; In dichloromethane;
DOI:10.1016/0040-4020(96)00288-8