Technology Process of (αR,βR)-β-ethyl-N,N,α-trimethyl-3-(phenylinethoxy)benzenepropanamide
There total 9 articles about (αR,βR)-β-ethyl-N,N,α-trimethyl-3-(phenylinethoxy)benzenepropanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 1h;
Cooling with ice;
- Guidance literature:
-
(αR,βR)-β-ethyl-α-methyl-3-(phenylmethoxy) benzenepropanoic acid;
With
thionyl chloride; N,N-dimethyl-formamide;
In
toluene;
at 30 ℃;
for 1.16667h;
Inert atmosphere;
N,N-dimethylammonium chloride;
With
potassium carbonate;
In
toluene;
at 20 - 55 ℃;
for 2.23333h;
Temperature;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere
1.2: 4 h / -78 - -20 °C / Inert atmosphere
2.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere
3.1: oxalyl dichloride / dichloromethane / 2 h / 40 °C / Inert atmosphere
4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
With
oxalyl dichloride; lithium hydroxide monohydrate; dihydrogen peroxide; sodium hexamethyldisilazane; triethylamine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetasy.2012.03.012
