(3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one

Base Information

Chemical Name:(3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one
CAS No.:263559-17-7
Molecular Formula:C₃₂H₄₁NO₄Si
Molecular Weight:531.767
Hs Code.:

Synonyms:(3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one

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Chemical Property of (3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one

Chemical Property:

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Technology Process of (3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one

There total 6 articles about (3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1749-08-2
N-(4-methoxy benzylidene)-4-methoxyaniline

: 263559-16-6
(3R)-S-2-pyridylthio 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-phenylvalerate

: 263559-17-7
(3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one

Guidance literature:: (3R)-S-2-pyridylthio 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-phenylvalerate; With titanium tetrachloride; triethylamine; In dichloromethane; at -78 ℃; for 0.25h;

N-(4-methoxy benzylidene)-4-methoxyaniline; In dichloromethane; at -78 - 20 ℃;
DOI:10.1016/S0957-4166(99)00566-2

Reference yield:

: 153744-07-1
(R)-3-hydroxy-5-phenylvaleric acid

: 263559-17-7
(3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: imidazole / CH₂Cl₂ / 20 °C

2.1: aq. K₂CO₃ / methanol; tetrahydrofuran / 2 h

3.1: PPh₃ / CH₂Cl₂ / 24 h / 20 °C

4.1: TiCl₄; Et₃N / CH₂Cl₂ / 0.25 h / -78 °C

4.2: CH₂Cl₂ / -78 - 20 °C

With 1H-imidazole; titanium tetrachloride; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 1.1: Silylation / 2.1: Hydrolysis / 3.1: Condensation / 4.1: Enolization / 4.2: Cycloaddition;
DOI:10.1016/S0957-4166(99)00566-2

Reference yield:

: 17071-29-3
ethyl 3-oxo-5-phenylpentanoate

: 263559-17-7
(3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: KOH

2.1: baker's yeast; glucose; MgSO₄ / H₂O / 168000 h

3.1: imidazole / CH₂Cl₂ / 20 °C

4.1: aq. K₂CO₃ / methanol; tetrahydrofuran / 2 h

5.1: PPh₃ / CH₂Cl₂ / 24 h / 20 °C

6.1: TiCl₄; Et₃N / CH₂Cl₂ / 0.25 h / -78 °C

6.2: CH₂Cl₂ / -78 - 20 °C

With 1H-imidazole; potassium hydroxide; baker's yeast; D-glucose; titanium tetrachloride; magnesium sulfate; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: Hydrolysis / 2.1: Enzymatic reduction / 3.1: Silylation / 4.1: Hydrolysis / 5.1: Condensation / 6.1: Enolization / 6.2: Cycloaddition;
DOI:10.1016/S0957-4166(99)00566-2