153744-07-1

Upstream product

• 30414-58-5 methyl 3-oxo-5-phenylpentanoate 
• 2270-20-4 5-Phenylpentanoic acid 
• 104-53-0 3-phenyl-propionaldehyde 
• 182417-58-9 (R)-3-hydroxy-5-phenyl-pentanoic acid ethyl ester 
• 17071-29-3 ethyl 3-oxo-5-phenylpentanoate 

Downstream Products

• 118133-67-8 (-)-(R)-methyl 3-hydroxy-5-phenylpentanoate 
• 116332-80-0 (2R,6R)-2-(tert-butyl)-6-(2'-phenylethyl)-1,3-dioxan-4-one 
• 263559-19-9 C₂₃H₄₂O₃Si₂ 
• 148260-92-8 SCH 48461 
• 263559-20-2 3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoic acid 
• 263559-16-6 (3R)-S-2-pyridylthio 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-phenylvalerate 
• 263559-11-1 (3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[(1-hydroxy-3-phenyl)propyl]azetidin-2-one 
• 263559-23-5 Imidazole-1-carbothioic acid O-{(R)-1-[(2S,3S)-1,2-bis-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-3-phenyl-propyl} ester 
• 263559-17-7 (3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one 

Relevant academic research and scientific papers

Diastereoselective synthesis of polypropionates: Cationic couplings of 4-acetoxy-1,3-dioxanes with crotyl-metal reagents

Lewis acids promote the coupling of 4-acetoxy-1,3-dioxanes 1 with crotyl-metal species to generate propionate motifs such as 2. The reactions show a marked dependence on Lewis acid, the crotyl metal species, and the presence and stereochemical disposition of a C5 methyl group. A 1,3-syn methyl relationship is favored in these additions.

Tailored biosynthesis of olefinic medium-chain-length poly[(R)-3-hydroxyalkanoates] in pseudomonas putida GPo1 with improved thermal properties

Mixtures of 5-phenylvalerate, octanoate, and 10-undecenoate were fed to a chemostat culture (dilution rate = 0.1 h-1) of Pseudomonas putida GPo1 under well-defined dual-(C,N)-nutrient limited growth conditions. Five new, tailor-made copolymers

Stereoselective synthesis of 2-azetidinones as cholesterol-absorption inhibitors

The synthesis of two 2-azetidinones possessing powerful cholesterol- absorption inhibition properties has been accomplished by a short and highly stereoselective reaction sequence. The key step is the condensation of the titanium enolate of the easily prepared 2-pyridylthioester (R)-11 with imine 6 which affords the desired β-lactam intermediate in the correct relative and absolute configuration. Conversion to the pharmacologically active compounds is readily accomplished by simple functional group manipulation. (C) 2000 Elsevier Science Ltd.

Enantioselective synthesis of (+)- and (-)-dihydrokawain

The first asymmetric synthesis of (+)- and (-)-dihydrokawain, an α-dihydropyrone isolated from the roots of Piper mythisticum, is reported. (+)-Dihydrokawain is the natural product and is of S-configuration.

New chiral acetate imide enolate for stereoselective aldol reactions

The chiral imide acetate 4 reacts upon lithium and titanium enolate formation conditions with aldehydes in a stereoselective manner. Remarkably, aldols obtained from aromatic and α,β-unsaturated aldehydes exhibited opposite stereochemistry than those obtained from aliphatic aldehydes.