153744-07-1

Basic information

• Product Name: (R)-3-hydroxy-5-phenylvaleric acid
• Synonyms: (R)-3-hydroxy-5-phenylvaleric acid
• CAS NO: 153744-07-1
• Molecular Weight: 194.23
• Mol File: 153744-07-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-3-hydroxy-5-phenylvaleric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-hydroxy-5-phenylvaleric acid(153744-07-1)
• EPA Substance Registry System: (R)-3-hydroxy-5-phenylvaleric acid(153744-07-1)

Safety Data

• Hazardous Substances Data: 153744-07-1(Hazardous Substances Data)

Upstream product

• 2270-20-4 5-Phenylpentanoic acid 
• 104-53-0 3-phenyl-propionaldehyde 
• 17071-29-3 ethyl 3-oxo-5-phenylpentanoate 
• 182417-58-9 (R)-3-hydroxy-5-phenyl-pentanoic acid ethyl ester 
• 30414-58-5 methyl 3-oxo-5-phenylpentanoate 

Downstream Products

• 116332-80-0 (2R,6R)-2-(tert-butyl)-6-(2'-phenylethyl)-1,3-dioxan-4-one 
• 263559-17-7 (3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-phenylpropyl]azetidin-2-one 
• 263559-23-5 Imidazole-1-carbothioic acid O-{(R)-1-[(2S,3S)-1,2-bis-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-3-phenyl-propyl} ester 
• 263559-11-1 (3'R,3S,4S)-1,4-di(4-methoxyphenyl)-3-[(1-hydroxy-3-phenyl)propyl]azetidin-2-one 
• 263559-16-6 (3R)-S-2-pyridylthio 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-phenylvalerate 
• 263559-20-2 3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoic acid 
• 148260-92-8 SCH 48461 
• 263559-19-9 C₂₃H₄₂O₃Si₂ 
• 118133-67-8 (-)-(R)-methyl 3-hydroxy-5-phenylpentanoate 

Relevant articles and documents

Diastereoselective synthesis of polypropionates: Cationic couplings of 4-acetoxy-1,3-dioxanes with crotyl-metal reagents

Lewis acids promote the coupling of 4-acetoxy-1,3-dioxanes 1 with crotyl-metal species to generate propionate motifs such as 2. The reactions show a marked dependence on Lewis acid, the crotyl metal species, and the presence and stereochemical disposition of a C5 methyl group. A 1,3-syn methyl relationship is favored in these additions.

Stereoselective synthesis of 2-azetidinones as cholesterol-absorption inhibitors

The synthesis of two 2-azetidinones possessing powerful cholesterol- absorption inhibition properties has been accomplished by a short and highly stereoselective reaction sequence. The key step is the condensation of the titanium enolate of the easily prepared 2-pyridylthioester (R)-11 with imine 6 which affords the desired β-lactam intermediate in the correct relative and absolute configuration. Conversion to the pharmacologically active compounds is readily accomplished by simple functional group manipulation. (C) 2000 Elsevier Science Ltd.

Enantioselective synthesis of (+)- and (-)-dihydrokawain

The first asymmetric synthesis of (+)- and (-)-dihydrokawain, an α-dihydropyrone isolated from the roots of Piper mythisticum, is reported. (+)-Dihydrokawain is the natural product and is of S-configuration.