2,2',2''-(10-(2-((2-(4-(diphenylphosphino)benzamido)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Base Information

Chemical Name:2,2',2''-(10-(2-((2-(4-(diphenylphosphino)benzamido)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
CAS No.:1618093-96-1
Molecular Formula:C₃₇H₄₇N₆O₈P
Molecular Weight:734.789
Hs Code.:

Synonyms:2,2',2''-(10-(2-((2-(4-(diphenylphosphino)benzamido)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

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Chemical Property of 2,2',2''-(10-(2-((2-(4-(diphenylphosphino)benzamido)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

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Technology Process of 2,2',2''-(10-(2-((2-(4-(diphenylphosphino)benzamido)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

There total 6 articles about 2,2',2''-(10-(2-((2-(4-(diphenylphosphino)benzamido)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 2,2',2''-(10-(2-((2-aminoethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

: 1194506-14-3
succinimid-N-yl 4-(diphenylphosphino)benzoate

: 1618093-96-1
2,2',2''-(10-(2-((2-(4-(diphenylphosphino)benzamido)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: succinimid-N-yl 4-(diphenylphosphino)benzoate; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

2,2',2''-(10-(2-((2-aminoethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201300494

Reference yield:

: 829-85-6
diphenylphosphane

: 1618093-96-1
2,2',2''-(10-(2-((2-(4-(diphenylphosphino)benzamido)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; triethylamine / acetonitrile / 72 h / Inert atmosphere; Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With palladium diacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1002/cmdc.201300494

Reference yield:

: tris(tert-butyl) 2,2',2''-(1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate hydrobromide

: 1618093-96-1
2,2',2''-(10-(2-((2-(4-(diphenylphosphino)benzamido)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 24 h / 40 °C

2.1: 120 h / 20 °C

3.1: hydrogenchloride / water / 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In water; acetonitrile;
DOI:10.1002/cmdc.201300494