N-(2-(1-acetyl-1H-benzo[d]imidazol-2-yl)ethyl)-2-(4-bromophenoxy)acetamide

Base Information

Chemical Name:N-(2-(1-acetyl-1H-benzo[d]imidazol-2-yl)ethyl)-2-(4-bromophenoxy)acetamide
CAS No.:1574223-46-3
Molecular Formula:C₁₉H₁₈BrN₃O₃
Molecular Weight:416.274
Hs Code.:

Synonyms:N-(2-(1-acetyl-1H-benzo[d]imidazol-2-yl)ethyl)-2-(4-bromophenoxy)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-(1-acetyl-1H-benzo[d]imidazol-2-yl)ethyl)-2-(4-bromophenoxy)acetamide

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Technology Process of N-(2-(1-acetyl-1H-benzo[d]imidazol-2-yl)ethyl)-2-(4-bromophenoxy)acetamide

There total 4 articles about N-(2-(1-acetyl-1H-benzo[d]imidazol-2-yl)ethyl)-2-(4-bromophenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-2-(4-bromophenoxy)acetamide

: 75-36-5
acetyl chloride

: 1574223-46-3
N-(2-(1-acetyl-1H-benzo[d]imidazol-2-yl)ethyl)-2-(4-bromophenoxy)acetamide

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm401709b

Reference yield:

: 16738-06-0
4-bromophenoxyacetyl chloride

: 1574223-46-3
N-(2-(1-acetyl-1H-benzo[d]imidazol-2-yl)ethyl)-2-(4-bromophenoxy)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 2.25 h

2.1: diethyl ether; hexane / 0.25 h / 20 °C

2.2: 1.25 h / 20 °C

3.1: dmap; pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; triethylamine; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401709b

Reference yield:

: 1878-91-7
(4-bromophenoxy)acetic acid

: 1574223-46-3
N-(2-(1-acetyl-1H-benzo[d]imidazol-2-yl)ethyl)-2-(4-bromophenoxy)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 2.25 h

3.1: diethyl ether; hexane / 0.25 h / 20 °C

3.2: 1.25 h / 20 °C

4.1: dmap; pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; oxalyl dichloride; triethylamine; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401709b