1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide

Base Information

Chemical Name:1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide
CAS No.:175870-40-3
Molecular Formula:C₃₂H₃₈F₃N₃O₄
Molecular Weight:585.667
Hs Code.:

Synonyms:1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide

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Chemical Property of 1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide

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Technology Process of 1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide

There total 16 articles about 1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.4%

: 87-69-4,138508-61-9
L-Tartaric acid

: 3-7-cyano-5-(R)-2-(R)-1-phenylethylamino propyl-1-H-indolylpropyl-4-fluorobenzoate

: 175870-40-3
1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide

Guidance literature:: 3-7-cyano-5-(R)-2-(R)-1-phenylethylamino propyl-1-H-indolylpropyl-4-fluorobenzoate; With hydrogenchloride; palladium on activated charcoal; In methanol; water; at 40 - 80 ℃; under 1520.1 - 7600.51 Torr;

L-Tartaric acid; In acetone; at 40 ℃; Reflux;

Reference yield:

: 459868-77-0
2,3-dihydro-1-[3-(phenylmethoxy)propyl]-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

: 175870-40-3
1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In water; dimethyl sulfoxide; at 20 ℃; for 20.1667h; Cooling with ice; Inert atmosphere;

Reference yield:

: 100-39-0
benzyl bromide

: 175870-40-3
1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 22 h / Reflux

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25.5 h / 130 °C

3.1: trichlorophosphate / 1 h / 0 - 5 °C

3.2: 21.17 h / 20 °C / Cooling

3.3: 4 h / 35 °C

4.1: bromine; acetic acid / 0.67 h / 20 °C

5.1: N,N-dimethyl-formamide / 150 °C / Inert atmosphere

5.2: 0.25 h / 70 °C

6.1: ammonium acetate / 4.5 h / 125 °C

6.2: 0.5 h / 20 °C

7.1: hydrogenchloride; water; iron; iron(III) chloride / 2.5 h / 60 - 90 °C

8.1: tetrahydrofuran / 0.17 h / 20 °C

8.2: 24 h / 20 °C

9.1: sodium carbonate / water / 0.5 h / 20 °C

10.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 21.5 h / 110 °C / Sealed tube

11.1: hydrogen / 5%-palladium/activated carbon / ethanol / 19 h / 50 °C / 9000.9 Torr

12.1: sodium hydroxide; dihydrogen peroxide / water; dimethyl sulfoxide / 20.17 h / 20 °C / Cooling with ice; Inert atmosphere

With hydrogenchloride; iron(III) chloride; ammonium acetate; water; hydrogen; dihydrogen peroxide; bromine; iron; sodium carbonate; potassium carbonate; acetic acid; potassium iodide; sodium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;