1-(2-Bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Base Information

• Chemical Name: 1-(2-Bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene
• CAS No.: 160969-00-6
• Molecular Formula: C10H10BrF3O2
• Molecular Weight: 299.087
• European Community (EC) Number: 851-936-9
• DSSTox Substance ID: DTXSID50602331
• Nikkaji Number: J3.160.216E
• Wikidata: Q72511095
• Mol file: 160969-00-6.mol

Synonyms:160969-00-6;1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene;2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl bromide;Benzene, 1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)-;2-2-(2,2,2-trifluoroethoxy)phenoxyethyl bromide;SCHEMBL2380358;DTXSID50602331;BCP11392;AKOS015890260;AC-23948;AS-69465;AM20090782;A810208;A1-02006;1-(2,2,2-Trifluoroethoxy)-2-(2-bromoethoxy)benzene;2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl bromide

Chemical Property of 1-(2-Bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Chemical Property:

• Appearance/Colour: cream
• Vapor Pressure: 0.00948mmHg at 25°C
• Refractive Index: 1.482
• Boiling Point: 273.6 °C at 760 mmHg
• Flash Point: 148 °C
• PSA: 18.46000
• Density: 1.495 g/cm³
• LogP: 3.40140
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 297.98163
• Heavy Atom Count: 16
• Complexity: 199

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)OCCBr)OCC(F)(F)F

Technology Process of 1-(2-Bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene

There total 4 articles about 1-(2-Bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-O-(2,2,2-trifluoroethyl)catechol (160968-99-0) + ethylene dibromide (106-93-4) → 1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene (160969-00-6)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; at 60 ℃; for 48h;

DOI:10.3390/molecules23092175

Reference yield:

1,1,1-trifluoro-2-iodoethane (353-83-3) + 2-methoxy-phenol (90-05-1) → 2-methoxy-1-(2,2,2-trifluoroethoxy)benzene (106854-74-4) + 1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene (160969-00-6)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide;

Reference yield:

2-methoxy-phenol (90-05-1) → 1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene (160969-00-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 90 °C

2: boron tribromide / dichloromethane / 2 h

3: potassium carbonate; potassium iodide / acetone / 48 h / 60 °C

With boron tribromide; potassium carbonate; potassium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.3390/molecules23092175

upstream raw materials:

1,1,1-trifluoro-2-iodoethane

2-methoxy-phenol

2-O-(2,2,2-trifluoroethyl)catechol

ethylene dibromide

Downstream raw materials:

1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile

(-)-2-Methoxy-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]benzenesulfonamide

silodosin

2,3-dihydro-1-[3-(phenylmethoxy)propyl]-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile