N-benzyl-N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl}-hydroxylamine

Base Information

• Chemical Name: N-benzyl-N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl}-hydroxylamine
• CAS No.: 810675-87-7
• Molecular Formula: C₃₅H₄₁NO₂Si
• Molecular Weight: 535.802

Synonyms:N-benzyl-N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl}-hydroxylamine

Chemical Property of N-benzyl-N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl}-hydroxylamine

Chemical Property:

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Technology Process of N-benzyl-N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl}-hydroxylamine

There total 3 articles about N-benzyl-N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl}-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide (810675-86-6) + methylmagnesium bromide (75-16-1) → N-benzyl-N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl}-hydroxylamine (810675-87-7)

Guidance literature:

With magnesium bromide; In tetrahydrofuran; diethyl ether; toluene; at -78 ℃; for 8h;

DOI:10.1021/jo048637e

Reference yield:

(1R,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropanecarbaldehyde → N-benzyl-N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl}-hydroxylamine (810675-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / 2 h / 20 °C

2: 50 percent / MgBr₂ / diethyl ether; tetrahydrofuran; toluene / 8 h / -78 °C

With magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 2: Grignard addition;

DOI:10.1021/jo048637e

Reference yield:

N-benzylhydroxylamine hydrochloride (29601-98-7) → N-benzyl-N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl}-hydroxylamine (810675-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / 2 h / 20 °C

2: 50 percent / MgBr₂ / diethyl ether; tetrahydrofuran; toluene / 8 h / -78 °C

With magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 2: Grignard addition;

DOI:10.1021/jo048637e

upstream raw materials:

(Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide

methylmagnesium bromide

N-benzylhydroxylamine hydrochloride

Downstream raw materials:

(1S,2R)-2-[(S)-1-(benzylamino)ethyl]-1-tert-butyldiphenylsilyloxymethyl-1-phenylcyclopropane

(1S,2R)-2-[(S)-1-(benzylamino)ethyl]-1-hydroxymethyl-1-phenylcyclopropane

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