Multi-step reaction with 6 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere; Sealed tube
2: (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; zinc; palladium diacetate; sulfuric acid / N,N-dimethyl acetamide / 3.5 h / 100 °C / Inert atmosphere
3: N-Bromosuccinimide / chloroform / 1 h / Reflux
4: N-ethyl-N,N-diisopropylamine; potassium fluoride / dimethyl sulfoxide / 16 h / 100 °C / Sealed tube
5: hydroxylamine hydrochloride; sodium hydrogencarbonate / water; ethanol / 1 h / 100 °C
6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; N-Bromosuccinimide; sulfuric acid; hydroxylamine hydrochloride; palladium diacetate; sodium hydrogencarbonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; zinc;
In
1,4-dioxane; ethanol; chloroform; N,N-dimethyl acetamide; water; dimethyl sulfoxide; acetonitrile;