thymoxyacetonitrile

Base Information

• Chemical Name: thymoxyacetonitrile
• CAS No.: 855938-62-4
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.257
• Mol file: 855938-62-4.mol

Synonyms:thymoxyacetonitrile

Chemical Property of thymoxyacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of thymoxyacetonitrile

There total 5 articles about thymoxyacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.7%

thymol (89-83-8) → thymoxyacetonitrile (855938-62-4)

Guidance literature:

thymol; With potassium carbonate; In acetone; at 0 ℃; for 0.333333h;

2-haloacetonitrile; In acetone; at 20 ℃; for 4h;

DOI:10.1021/acs.jafc.0c07439

Reference yield:

thymol (89-83-8) + chloroacetonitrile (107-14-2) → thymoxyacetonitrile (855938-62-4)

Guidance literature:

With potassium carbonate; acetone;

Reference yield:

thymoxyacetaldehyde → thymoxyacetonitrile (855938-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride, sodium hydroxide / aq. ethanol; H₂O / Ambient temperature

2: acetic anhydride / Heating

With sodium hydroxide; hydroxylamine hydrochloride; acetic anhydride; In ethanol; water;

upstream raw materials:

thymol

chloroacetonitrile

Downstream raw materials:

2-(2-isopropyl-5-methyl-phenoxy)-N,N-dimethyl-acetamidine; hydrochloride

(thymyloxy)acetamidine hydrochloride

2-(2-isopropyl-5-methyl-phenoxy)-N-methyl-acetamidine; hydrochloride

2-(thymoxymethyl)-4-(5'-nitro-2'-furyl)thiazole

Refernces

• 1、 Khadse, B. G.,Lokhande, S. R.,Bhamaria, R. P.,Prabhu, S. R.. "Synthesis and Antitubercular Activity of 4-(5-Nitro-2-furyl/2-pyrazinyl/1-adamantyl)-2-(alkyl/aryl/arylamino)thiazoles". . p. 856 - 860. Retrieved 2007/10/02.