(1r,1'R,4R)-6'-(2,3-difluorophenyl)-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

Base Information

Chemical Name:(1r,1'R,4R)-6'-(2,3-difluorophenyl)-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine
CAS No.:1383983-85-4
Molecular Formula:C₂₄H₂₅F₂N₃O
Molecular Weight:409.479
Hs Code.:

Synonyms:(1r,1'R,4R)-6'-(2,3-difluorophenyl)-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

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Chemical Property of (1r,1'R,4R)-6'-(2,3-difluorophenyl)-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

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Technology Process of (1r,1'R,4R)-6'-(2,3-difluorophenyl)-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

There total 8 articles about (1r,1'R,4R)-6'-(2,3-difluorophenyl)-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1384082-50-1
(1r,1'R,4R)-6'-bromo-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazole]-4-amine

: 121219-16-7
(2,3-difluorophenyl)boronic acid

: 1383983-85-4
(1r,1'R,4R)-6'-(2,3-difluorophenyl)-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 2-methyltetrahydrofuran; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1245515-16-5
6'-bromo-4-methoxyspiro[cyclohexane-1,2'-indene]-1'(3'H)-one

: 1383983-85-4
(1r,1'R,4R)-6'-(2,3-difluorophenyl)-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 26 h / Reflux

2: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

3: methanol / 15 h / 60 °C / Inert atmosphere

4: ammonia / methanol / 74 °C

5: diethylamine / carbon dioxide; methanol

6: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 2-methyltetrahydrofuran / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; titanium(IV) tetraethanolate; ammonia; sodium carbonate; diethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 2-methyltetrahydrofuran; 1,4-dioxane; methanol; carbon dioxide;

Reference yield:

: 1383985-58-7
6'-bromo-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-imine

: 1383983-85-4
(1r,1'R,4R)-6'-(2,3-difluorophenyl)-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 15 h / 60 °C / Inert atmosphere

2: ammonia / methanol / 74 °C

3: diethylamine / carbon dioxide; methanol

4: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 2-methyltetrahydrofuran / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With ammonia; sodium carbonate; diethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 2-methyltetrahydrofuran; methanol; carbon dioxide;