(+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol

Base Information

• Chemical Name: (+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol
• CAS No.: 109765-70-0
• Molecular Formula: C₂₂H₂₆FNO₂
• Molecular Weight: 355.452
• Mol file: 109765-70-0.mol

Synonyms:(+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol

Chemical Property of (+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol

There total 2 articles about (+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-(α)-1-benzyl-3-methyl-4-phenyl-4-piperidinol hydrochloride (109765-66-4) → (+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol (109765-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol; H₂O / 24 h / 50 - 60 °C / 1520 Torr

2: KI, Na₂CO₃ / toluene / 48 h / Heating

With hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; water; toluene;

DOI:10.1021/jm00393a037

Reference yield:

(+/-)-α-4-hydroxy-3-methyl-4-phenylpiperidine (109765-68-6) + 4-(4-fluorophenyl)-4-oxo-n-butyl chloride (3874-54-2,41167-07-1) → (+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol (109765-70-0)

Guidance literature:

With sodium carbonate; potassium iodide; In toluene; for 48h; Heating;

DOI:10.1021/jm00393a037

Reference yield: 68.0%

propionic acid anhydride (123-62-6) + (+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-piperidinol (109765-70-0) → (+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine (109765-73-3,130549-78-9)

Guidance literature:

With pyridine; for 2h; Heating;

DOI:10.1021/jm00393a037

upstream raw materials:

(+/-)-α-4-hydroxy-3-methyl-4-phenylpiperidine

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

(+/-)-(α)-1-benzyl-3-methyl-4-phenyl-4-piperidinol hydrochloride

Downstream raw materials:

(+/-)-(α)-1-<3-(p-fluorobenzoyl)propyl>-3-methyl-4-phenyl-4-(propionyloxy)piperidine