C₁₆H₁₇N₃

Base Information

• Chemical Name: C₁₆H₁₇N₃
• CAS No.: 1612157-12-6
• Molecular Formula: C₁₆H₁₇N₃
• Molecular Weight: 251.331
• Mol file: 1612157-12-6.mol

Synonyms:C₁₆H₁₇N₃

Chemical Property of C₁₆H₁₇N₃

Chemical Property:

Purity/Quality:

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Technology Process of C₁₆H₁₇N₃

There total 3 articles about C₁₆H₁₇N₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-Methylbenzimidazole (1632-83-3) + 3-chloro-N,N-dimethylaniline (6848-13-1) → C16H17N3 (1612157-12-6)

Guidance literature:

With NHC-Pd(II)-Im; potassium tert-butylate; In water; toluene; at 120 ℃; for 6h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jo5010058

Reference yield: 78.0%

1-Methylbenzimidazole (1632-83-3) + 3-methoxy-N,N-dimethylaniline (15799-79-8) → C16H17N3 (1612157-12-6)

Guidance literature:

With ortho-tolylmagnesium bromide; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; C₂₃H₃₀N₄; In m-xylene; at 90 ℃; for 16h;

DOI:10.1021/acscatal.8b03436

Reference yield: 67.0%

1-Methylbenzimidazole (1632-83-3) + norneostigmine (16088-19-0) → C16H17N3 (1612157-12-6)

Guidance literature:

With nickel(II) triflate; potassium phosphate; 1,2-bis-(dicyclohexylphosphino)ethane; In tert-Amyl alcohol; at 110 ℃;

DOI:10.1039/c5sc02942b

upstream raw materials:

1-Methylbenzimidazole

3-chloro-N,N-dimethylaniline

norneostigmine

3-methoxy-N,N-dimethylaniline

Refernces

• 1、 Muto, Kei,Hatakeyama, Taito,Yamaguchi, Junichiro,Itami, Kenichiro. "C-H arylation and alkenylation of imidazoles by nickel catalysis: Solvent-accelerated imidazole C-H activation". . p. 6792 - 6798. Retrieved 2015/11/24.