6848-13-1

Basic information

• Product Name: 3-CHLORO-N,N-DIMETHYLANILINE
• Synonyms: N,N-Dimethyl-3-chloroaniline;3-Dimethylamino-1-chlorobenzene;3-Chloro-N,N-dimethylaniline;N1,N1-DIMETHYL-3-CHLOROANILINE;TIMTEC-BB SBB008273;3-chloro-n,n-dimethyl-benzenamin;Benzenamine,3-chloro-N,N-dimethyl-;m-Chloro-N,N-dimethylaniline
• CAS NO: 6848-13-1
• Molecular Formula: C₈H₁₀ClN
• Molecular Weight: 155.62
• EINECS: 229-935-4
• Product Categories: Intermediates of Dyes and Pigments
• Mol File: 6848-13-1.mol
• Article Data: 45

Chemical Properties

• Boiling Point: 230-232°C
• Flash Point: 230-232°C
• Appearance: /
• Density: 1.1177 (rough estimate)
• Vapor Pressure: 0.058mmHg at 25°C
• Refractive Index: 1.5760
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 3.83(at 20℃)
• Water Solubility: Not miscible or difficult to mix in water.
• BRN: 2206152
• CAS DataBase Reference: 3-CHLORO-N,N-DIMETHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-N,N-DIMETHYLANILINE(6848-13-1)
• EPA Substance Registry System: 3-CHLORO-N,N-DIMETHYLANILINE(6848-13-1)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 28-36/37
• RIDADR: 2810
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 6848-13-1(Hazardous Substances Data)

Usage

Description

3-CHLORO-N,N-DIMETHYLANILINE is an organic compound with the chemical formula C8H10ClN. It is a derivative of aniline, where a chlorine atom is attached to the third carbon and two methyl groups are attached to the nitrogen atom. 3-CHLORO-N,N-DIMETHYLANILINE is a versatile intermediate in the synthesis of various organic compounds and has potential applications in different industries.

Uses

Used in Chemical Synthesis:
3-CHLORO-N,N-DIMETHYLANILINE is used as a chemical intermediate for the production of 3-(3-dimethylamino-phenyl)-acrylic acid butyl ester. This synthesis occurs at a temperature of 140°C in the presence of reagent Na2CO3 and solvent N,N-dimethyl-acetamide, with a reaction time of 20 hours.
3-CHLORO-N,N-DIMETHYLANILINE can be further utilized in various chemical reactions to produce a range of organic compounds, making it valuable in the chemical and pharmaceutical industries. Its unique structure allows for the formation of various functional groups, enabling the synthesis of target molecules with specific properties and applications.

InChI:InChI=1/C8H10ClN/c1-10(2)8-5-3-4-7(9)6-8/h3-6H,1-2H3

Upstream product

• 67-56-1 methanol 
• 124-38-9 carbon dioxide 
• 121-73-3 3-Nitrochlorobenzene 
• 64-18-6 formic acid 
• 7006-52-2 3-chloro-N-methylaniline 
• 2373-41-3 (3-chlorophenyl)trimethylammonium iodide 
• 108-42-9 3-chloro-aniline 
• 74-88-4 methyl iodide 
• 825-81-0 m-chloro-N,N-dimethylaniline-N-oxide 
• 616-38-6 carbonic acid dimethyl ester 
• 67-68-5 dimethyl sulfoxide 
• 50-00-0 formaldehyd 
• 31468-21-0 9-methylfluorenyl carboanion 
• 104322-38-5 N-(p-methoxybenzyl)-N,N-dimethyl-m-chloroanilinium bromide 

Downstream Products

• 4243-20-3 N-(3-chlorophenyl)-N-methylnitrous amide 
• 5428-29-5 4,4′-methylenebis(3-chloro-N,N-dimethylaniline) 
• 942069-59-2 3-chloro-N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1341225-35-1 C₁₉H₁₈N₂ 
• 1341225-42-0 C₂₇H₂₇N₃ 
• 1341225-38-4 C₁₇H₁₇N₃ 
• 1341225-46-4 C₂₅H₂₆N₄ 
• 121-72-2 N,N-dimethyl-m-toluidine 
• 447462-70-6 (R)-4-oxo-2-(4-dimethylamino-2-chlorophenyl)-butyric acid methyl ester 
• 141816-10-6 3-chloro-2-nitro-N,N-dimethylaniline 
• 17815-98-4 3-chloro-4-nitro-N,N-dimethylaniline 
• 98490-65-4 3-chloro-N,N-dimethyl-4-nitroso-aniline 
• 85654-74-6 2-chloro-4-dimethylamino-benzyl alcohol 

Relevant articles and documents

Additive-free selective methylation of secondary amines with formic acid over a Pd/In2O3 catalyst

Formic acid is used as the sole carbon and hydrogen source in the methylation of aromatic and aliphatic amines to methylamines. The reaction proceeds via a formylation/transfer hydrogenation pathway over a solid Pd/In2O3 catalyst without the need for any additive.

Method for realizing N-alkylation by using alcohols as carbon source under photocatalysis

The invention discloses a method for realizing N-alkylation by using alcohols as a carbon source under photocatalysis, and belongs to the technical field of catalytic synthesis. Alcohol, a substrate raw material and a catalyst are placed in a reaction device, ultraviolet and/or visible light irradiation is carried out in an inert atmosphere, after the irradiation is finished, solid-liquid separation is carried out to remove the catalyst, and an N-alkylation product can be obtained through extraction, distillation and purification, wherein the substrate raw material comprises any one of an amine compound, an aromatic nitro compound or an aromatic nitrile compound, the alcohol comprises any one or more of soluble primary alcohols, and the catalyst is metal oxide/titanium dioxide or metal sulfide/titanium dioxide. The method is simple and easy to operate, can be used for efficient photocatalysis one-pot multi-step hydrogenation N-alkylation reaction, and is mild in reaction condition, high in chemical selectivity of N-alkylamine, good in catalyst stability and easy to recycle.

Utilization of renewable formic acid from lignocellulosic biomass for the selective hydrogenation and/or N-methylation

Lignocellulosic biomass is one of the most abundant renewable sources in nature. Herein, we have developed the utilization of renewable formic acid from lignocellulosic biomass as a hydrogen source and a carbon source for the selective hydrogenation and further N-methylation of various quinolines and the derivatives, various indoles under mild conditions in high efficiencies. N-methylation of various anilines is also developed. Mechanistic studies indicate that the hydrogenation occurs via a transfer hydrogenation pathway.