16088-19-0

Usage

Uses

Used in Pharmaceutical Industry:
3-Dimethylaminophenyl dimethylcarbamate is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential neuromuscular blocking or stimulant properties. Its unique chemical structure allows it to be a versatile building block for the development of new drugs.
Used in Chemical Synthesis:
In the field of organic chemistry, 3-dimethylaminophenyl dimethylcarbamate serves as a key intermediate for the production of other complex organic molecules. Its reactivity and functional groups make it a valuable component in the synthesis of various chemical products, including agrochemicals, dyes, and specialty chemicals.
Used in Research and Development:
3-Dimethylaminophenyl dimethylcarbamate is also utilized in research and development settings, where it can be employed to study the effects of specific chemical modifications on the properties and activities of related compounds. Its use in this context aids in the advancement of scientific knowledge and the discovery of new applications for this class of compounds.

InChI:InChI=1/C11H16N2O2/c1-12(2)9-6-5-7-10(8-9)15-11(14)13(3)4/h5-8H,1-4H3

Upstream product

• 99-07-0 3-Dimethylaminophenol 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 
• 114-80-7 Neostigmine bromide 
• 75-44-5 phosgene 
• 124-40-3 dimethyl amine 
• 74-83-9 methyl bromide 
• 591-27-5 m-Hydroxyaniline 
• 7244-70-4 4-nitrophenyl dimethylcarbamate 
• 52177-71-6 3-(dimethylamino)phenyl carbonochloridate 

Downstream Products

• 6458-09-9 N-ethyl-3-dimethylcarbamoyloxy-N,N-dimethyl-anilinium; iodide 
• 1212-37-9 3-dimethylcarbamoyloxy-tri-N-methyl-anilinium; iodide 
• 1612157-12-6 C₁₆H₁₇N₃ 
• 1595291-52-3 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl dimethylcarbamate 
• 51-60-5 neostigmine methyl sulfate 
• 114-80-7 Neostigmine bromide 

Relevant academic research and scientific papers

Synthesis and preliminary pharmacology of an internal standard for assay of neostigmine

The synthesis of the diethyl analog of neostigmine, its preliminary pharmacology, and its use as an internal standard for the GLC assay of neostigmine are described. Both the diethyl analog and neostigmine undergo thermal demethylation in the injection port. The column selected produced satisfactory resolution and short retention times for neostigmine and the diethyl analog. The diethyl analog apparently possesses acetylcholinesterase inhibiting properties, as evidenced by potentiation of the contractile response to acetylcholine on the ileum. In addition, acetylcholine levels in the brain were elevated slightly. Water solutions of the diethyl analog appeared to lose biological activity with time. The diethyl analog appears to be suitable for use as an internal standard for the GLC assay of neostigmine.

PROCESS FOR PREPARATION OF HIGHLY PURE 3-DIMETHYLAMINOPHENYL DIMETHYLCARBAMATE

The invention discloses a novel process for preparation of highly pure 3-dimethylaminophenyl dimethylcarbamate via formation of aryl dimethylcarbamate which can be easily obtained from diaryl carbonate and dimethylamine.

Synthesis of some new o-substituted arylcarbamates and related compounds

Seven new 2-substituted-5-N',N'-dimethylaminophenyl N,N- dimethylcarbamates and three other compounds of similar structures have been synthesized aiming at obtaining potent anti-ChE agents. It has been found that the 2-substituents, regardless of their character, decrease the biological activity of the carbamates.