N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)picolinamide

Base Information

• Chemical Name: N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)picolinamide
• CAS No.: 1403990-54-4
• Molecular Formula: C₂₅H₁₇N₅O₂
• Molecular Weight: 419.442

Synonyms:N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)picolinamide

Chemical Property of N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)picolinamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)picolinamide

There total 4 articles about N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)-N′-phenylpicolinimidamide (1459721-93-7) → N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)picolinamide (1403990-54-4)

Guidance literature:

With acetic acid; at 120 ℃; for 1h;

DOI:10.1039/c3ob41169a

Reference yield: 86.0%

6-amino-1,3-diphenylbenzo[e][1,2,4]triazin-7-(1H)-one (1316792-97-8) + 2-picolinoyl chloride hydrochloride (39901-94-5) → N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)picolinamide (1403990-54-4)

Guidance literature:

6-amino-1,3-diphenylbenzo[e][1,2,4]triazin-7-(1H)-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h;

2-picolinoyl chloride hydrochloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 12h;

DOI:10.1021/ol302714j

Reference yield:

1,3-diphenylbenzo[e]-[1,2,4]triazin-7(1H)-one (22751-79-7) + N′-phenylpicolinamidine → N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)picolinamide (1403990-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / toluene / 72 h / 100 °C

2: acetic acid / 1 h / 120 °C

With acetic acid; N-ethyl-N,N-diisopropylamine; In toluene;

DOI:10.1039/c3ob41169a

upstream raw materials:

6-amino-1,3-diphenylbenzo[e][1,2,4]triazin-7-(1H)-one

2-picolinoyl chloride hydrochloride

1,3-diphenylbenzo[e]-[1,2,4]triazin-7(1H)-one

N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)-N′-phenylpicolinimidamide

Downstream raw materials:

1,3-diphenyl-7-pyridin-2-yl-1,4-dihydrothiazolo[5',4':4,5]benzo[1,2-e][1,2,4]-triazin-4-yl

N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)picolinethioamide

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