10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid

Base Information

• Chemical Name: 10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid
• CAS No.: 882685-63-4
• Molecular Formula: C₃₂H₄₂N₄O₁₀
• Molecular Weight: 642.706
• Mol file: 882685-63-4.mol

Synonyms:10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid

Chemical Property of 10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid

There total 5 articles about 10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid tris(1,1-dimethylethyl) ester (882685-65-6) → 10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (882685-63-4)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 4h;

DOI:10.1039/b514409d

Reference yield:

3-(4-acetylphenoxy)propyl benzoate → 10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (882685-63-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / N-bromosuccinimide; p-TsOH*H₂O / acetonitrile / 1 h / Heating

2: 91 percent / Na₂CO₃ / acetonitrile / 30 h / Heating

3: 92 percent / CF₃CO₂H / 4 h / 20 °C

With N-Bromosuccinimide; sodium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; In acetonitrile;

DOI:10.1039/b514409d

Reference yield:

3-[4-(2-bromoacetyl)phenoxy]propyl benzoate (882685-68-9) → 10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (882685-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Na₂CO₃ / acetonitrile / 30 h / Heating

2: 92 percent / CF₃CO₂H / 4 h / 20 °C

With sodium carbonate; trifluoroacetic acid; In acetonitrile;

DOI:10.1039/b514409d

upstream raw materials:

10-{4-[3-(benzoyloxy)propyloxy]benzoylmethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid tris(1,1-dimethylethyl) ester

3-[4-(2-bromoacetyl)phenoxy]propyl benzoate

3-bromopropyl benzoate

4-Hydroxyacetophenone