tert-butyl 4-<4-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate

Base Information

Chemical Name:tert-butyl 4-<4-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate
CAS No.:146943-42-2
Molecular Formula:C₂₂H₃₂N₄O₅
Molecular Weight:432.52
Hs Code.:

Synonyms:tert-butyl 4-<4-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate

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Chemical Property of tert-butyl 4-<4-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate

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Technology Process of tert-butyl 4-<4-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate

There total 6 articles about tert-butyl 4-<4-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 50-01-1
guanidine hydrochloride

: ethyl 6-<4-(tert-butoxycarbonyl)phenyl>-2-cyano-3-(dimethoxymethyl)hexanoate

: 146943-42-2
tert-butyl 4-<4-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate

Guidance literature:: With potassium n-butoxide; In tetrahydrofuran; tert-butyl alcohol; Heating;
DOI:10.1021/jo00059a016

Reference yield:

: 65874-27-3
4-(tert-butoxycarbonyl)benzaldehyde

: 146943-42-2
tert-butyl 4-<4-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1) NaH / 1) THF, reflux, 4 h, 2) THF, reflux, 1.5 h

2: 100 percent / H₂ / 10percent Pd/C / methanol / 4 h

3: 86 percent / oxalyl chloride, DMSO / CH₂Cl₂ / -60 °C

4: 1) t-BuOK / 1) THF, toluene, 2) toluene, 0 deg C

5: 1) CH₂Cl₂, molecular sieves 3A, UV, 0 - 5 deg C, 2 h, 2) 10 min

6: 80 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating

With oxalyl dichloride; potassium tert-butylate; hydrogen; sodium hydride; potassium n-butoxide; dimethyl sulfoxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00059a016

Reference yield:

: 146850-30-8
tert-butyl 4-(4-hydroxy-1-butenyl)benzoate

: 146943-42-2
tert-butyl 4-<4-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-5,5-dimethoxypentyl>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂ / 10percent Pd/C / methanol / 4 h

2: 86 percent / oxalyl chloride, DMSO / CH₂Cl₂ / -60 °C

3: 1) t-BuOK / 1) THF, toluene, 2) toluene, 0 deg C

4: 1) CH₂Cl₂, molecular sieves 3A, UV, 0 - 5 deg C, 2 h, 2) 10 min

5: 80 percent / 1 M BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / Heating

With oxalyl dichloride; potassium tert-butylate; hydrogen; potassium n-butoxide; dimethyl sulfoxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00059a016