(R)-2-bromo-1-tert-butyldimethylsilyloxy-1-(3-formamido-4-benzyloxyphenyl)ethane

Base Information

• Chemical Name: (R)-2-bromo-1-tert-butyldimethylsilyloxy-1-(3-formamido-4-benzyloxyphenyl)ethane
• CAS No.: 652990-08-4
• Molecular Formula: C₂₂H₃₀BrNO₃Si
• Molecular Weight: 464.475

Synonyms:(R)-2-bromo-1-tert-butyldimethylsilyloxy-1-(3-formamido-4-benzyloxyphenyl)ethane

Chemical Property of (R)-2-bromo-1-tert-butyldimethylsilyloxy-1-(3-formamido-4-benzyloxyphenyl)ethane

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of (R)-2-bromo-1-tert-butyldimethylsilyloxy-1-(3-formamido-4-benzyloxyphenyl)ethane

There total 3 articles about (R)-2-bromo-1-tert-butyldimethylsilyloxy-1-(3-formamido-4-benzyloxyphenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-[5-((1R)-2-bromo-1-hydroxyethyl)-2-(phenylmethoxy)phenyl]carboxamide (201677-59-0) + tert-butyldimethylsilyl chloride (18162-48-6) → (R)-2-bromo-1-tert-butyldimethylsilyloxy-1-(3-formamido-4-benzyloxyphenyl)ethane (652990-08-4)

Guidance literature:

With 1H-imidazole; In dichloromethane; for 22h; Product distribution / selectivity;

Reference yield:

N-(2-(benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide + tert-butyldimethylsilyl chloride (18162-48-6) → (R)-2-bromo-1-tert-butyldimethylsilyloxy-1-(3-formamido-4-benzyloxyphenyl)ethane (652990-08-4)

Guidance literature:

With 1H-imidazole; dmap; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

N-(2-(benzyloxy)-5-(2-bromo-1-hydroxyethyl)phenyl)formamide + C17H18BrNO3 + tert-butyldimethylsilyl chloride (18162-48-6) → (R)-2-bromo-1-tert-butyldimethylsilyloxy-1-(3-formamido-4-benzyloxyphenyl)ethane (652990-08-4) + C23H32BrNO3Si (929701-11-1)

Guidance literature:

With 1H-imidazole; dmap; In DMF (N,N-dimethyl-formamide); at 20 ℃;

upstream raw materials:

N-[5-((1R)-2-bromo-1-hydroxyethyl)-2-(phenylmethoxy)phenyl]carboxamide

tert-butyldimethylsilyl chloride

Downstream raw materials:

N-{5-[(R)-2-benzylamino-1-(tert-butyldimethylsilanyloxy)ethyl]-2-benzyloxyphenyl}formamide

3-[{(13R)-13-[4-(benzyloxy)-3-(formylamino)phenyl]-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl}(methyl)amino]benzamide

N-[5-((R)-2-{2-[4-((S)-2-hydroxy-2-phenylethylamino)phenyl]-ethylamino}-1-(tert-butyldimethylsilanyloxy)ethyl)-8-benzyloxyphenyl]formamide

N-[5-((R)-2-{2-[4-((S)-2-amino-2-phenylethylamino)phenyl]-ethylamino}-1-(tert-butyldimethylsilanyloxy)ethyl)-2-benzyloxyphenyl]formamide

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