3-[{(13R)-13-[4-(benzyloxy)-3-(formylamino)phenyl]-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl}(methyl)amino]benzamide

Base Information

Chemical Name:3-[{(13R)-13-[4-(benzyloxy)-3-(formylamino)phenyl]-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl}(methyl)amino]benzamide
CAS No.:956235-32-8
Molecular Formula:C₃₉H₅₈N₄O₅Si
Molecular Weight:690.999
Hs Code.:

Synonyms:3-[{(13R)-13-[4-(benzyloxy)-3-(formylamino)phenyl]-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl}(methyl)amino]benzamide

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Chemical Property of 3-[{(13R)-13-[4-(benzyloxy)-3-(formylamino)phenyl]-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl}(methyl)amino]benzamide

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Technology Process of 3-[{(13R)-13-[4-(benzyloxy)-3-(formylamino)phenyl]-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl}(methyl)amino]benzamide

There total 9 articles about 3-[{(13R)-13-[4-(benzyloxy)-3-(formylamino)phenyl]-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl}(methyl)amino]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 652990-08-4
(R)-2-bromo-1-tert-butyldimethylsilyloxy-1-(3-formamido-4-benzyloxyphenyl)ethane

: 956234-88-1
3-[{3-[(6-aminohexyl)oxy]propyl}(methyl)amino]benzamide

: 956235-32-8
3-[{(13R)-13-[4-(benzyloxy)-3-(formylamino)phenyl]-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl}(methyl)amino]benzamide

Guidance literature:: With potassium carbonate; sodium iodide; In dimethyl sulfoxide; at 120 ℃; for 1h;

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 956235-32-8
3-[{(13R)-13-[4-(benzyloxy)-3-(formylamino)phenyl]-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl}(methyl)amino]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / tetrabutylammomium bromide / water / 20 h / 20 °C

2: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 20 - 75 °C

3: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 4 h / 20 °C / 1965.2 Torr

4: triethylamine / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / 5 h / 120 °C

6: hydrazine / ethanol / 22 h / 20 °C

7: potassium carbonate; sodium iodide / dimethyl sulfoxide / 1 h / 120 °C

With sodium hydroxide; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; hydrazine; palladium 10% on activated carbon; tetrabutylammomium bromide; cetyltributylphosphonium bromide; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 956234-76-7
({3-[(6-bromohexyl)oxy]propoxy}methyl)benzene

: 956235-32-8
3-[{(13R)-13-[4-(benzyloxy)-3-(formylamino)phenyl]-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl}(methyl)amino]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 20 - 75 °C

2: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 4 h / 20 °C / 1965.2 Torr

3: triethylamine / dichloromethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / 5 h / 120 °C

5: hydrazine / ethanol / 22 h / 20 °C

6: potassium carbonate; sodium iodide / dimethyl sulfoxide / 1 h / 120 °C

With hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; hydrazine; palladium 10% on activated carbon; cetyltributylphosphonium bromide; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;