12-benzyl-8-hydroxy-2-[4-(trifluoromethyl)benzyl]-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one

Base Information

Chemical Name:12-benzyl-8-hydroxy-2-[4-(trifluoromethyl)benzyl]-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one
CAS No.:1397692-04-4
Molecular Formula:C₂₉H₂₀F₃N₃O₂
Molecular Weight:499.492
Hs Code.:

Synonyms:12-benzyl-8-hydroxy-2-[4-(trifluoromethyl)benzyl]-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one

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Chemical Property of 12-benzyl-8-hydroxy-2-[4-(trifluoromethyl)benzyl]-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one

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Technology Process of 12-benzyl-8-hydroxy-2-[4-(trifluoromethyl)benzyl]-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one

There total 8 articles about 12-benzyl-8-hydroxy-2-[4-(trifluoromethyl)benzyl]-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.7%

: 1397692-03-3
3-amino-2-benzylbenzo[f]quinoxalin-8-ol (14,v-coelenteramine)

: 1239112-43-6
1,1-diethoxy-3-[4-(trifluoromethyl)phenyl]propan-2-one

: 1397692-04-4
12-benzyl-8-hydroxy-2-[4-(trifluoromethyl)benzyl]-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one

Guidance literature:: With hydrogenchloride; In ethanol; water; at 0 - 80 ℃; for 13h; Inert atmosphere;

Reference yield:

: 1397691-95-0
2-amino-3-benzyl-5-bromo-6-chloropyrazine

: 1397692-04-4
12-benzyl-8-hydroxy-2-[4-(trifluoromethyl)benzyl]-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium fluoride / bis(η3-allyl-μ-chloropalladium(II)); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane / water; tetrahydrofuran / 14 h / 20 °C / Inert atmosphere

2.1: tetrabutyl-ammonium chloride / bis-triphenylphosphine-palladium(II) chloride / toluene / 1.5 h / Inert atmosphere; Reflux

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

3.2: 1.5 h / 0 - 20 °C / Inert atmosphere

4.1: pyridine / dmap / 1 h / 20 - 60 °C / Inert atmosphere

5.1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 17 h / 90 °C / Inert atmosphere

6.1: boron trifluoride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

7.1: methanol / 14 h / 65 °C

8.1: hydrogenchloride / ethanol; water / 13 h / 0 - 80 °C / Inert atmosphere

With pyridine; hydrogenchloride; methanol; potassium fluoride; n-butyllithium; boron trifluoride; tetrabutyl-ammonium chloride; dmap; bis-triphenylphosphine-palladium(II) chloride; Hoveyda-Grubbs catalyst second generation; bis(η3-allyl-μ-chloropalladium(II)); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.1: Suzuki-Miyaura coupling / 2.1: Stille Coupling;

Reference yield:

: 1397691-99-4
N-(3-benzyl-5-(4-methoxy-2-vinylphenyl)-6-vinylpyrazin-2-yl)acetamide

: 1397692-04-4
12-benzyl-8-hydroxy-2-[4-(trifluoromethyl)benzyl]-11H-benz[f]imidazo[1,2-a]quinoxalin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 17 h / 90 °C / Inert atmosphere

2: boron trifluoride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: methanol / 14 h / 65 °C

4: hydrogenchloride / ethanol; water / 13 h / 0 - 80 °C / Inert atmosphere

With hydrogenchloride; methanol; boron trifluoride; Hoveyda-Grubbs catalyst second generation; In ethanol; dichloromethane; water; 1,2-dichloro-ethane;