Technology Process of Benz[f]imidazo[1,2-a]quinoxalin-3(11H)-one, 8-hydroxy-2-[(4-hydroxyphenyl)methyl]-12-(phenylmethyl)-
There total 13 articles about Benz[f]imidazo[1,2-a]quinoxalin-3(11H)-one, 8-hydroxy-2-[(4-hydroxyphenyl)methyl]-12-(phenylmethyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethanol; water;
at 0 - 80 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium fluoride / bis(η3-allyl-μ-chloropalladium(II)); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane / water; tetrahydrofuran / 14 h / 20 °C / Inert atmosphere
2.1: tetrabutyl-ammonium chloride / bis-triphenylphosphine-palladium(II) chloride / toluene / 1.5 h / Inert atmosphere; Reflux
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
3.2: 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: pyridine / dmap / 1 h / 20 - 60 °C / Inert atmosphere
5.1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 17 h / 90 °C / Inert atmosphere
6.1: boron trifluoride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
7.1: methanol / 14 h / 65 °C
8.1: hydrogenchloride / ethanol; water / 0 - 80 °C / Inert atmosphere
With
pyridine; hydrogenchloride; methanol; potassium fluoride; n-butyllithium; boron trifluoride; tetrabutyl-ammonium chloride;
dmap; bis-triphenylphosphine-palladium(II) chloride; Hoveyda-Grubbs catalyst second generation; bis(η3-allyl-μ-chloropalladium(II)); di‐tert‐butyl‐(1‐phenylindol‐2‐yl)phosphane;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; 1,2-dichloro-ethane; toluene;
1.1: Suzuki-Miyaura coupling / 2.1: Stille Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 17 h / 90 °C / Inert atmosphere
2: boron trifluoride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
3: methanol / 14 h / 65 °C
4: hydrogenchloride / ethanol; water / 0 - 80 °C / Inert atmosphere
With
hydrogenchloride; methanol; boron trifluoride;
Hoveyda-Grubbs catalyst second generation;
In
ethanol; dichloromethane; water; 1,2-dichloro-ethane;
