2-<2-(3-cyano-2-methyl-1-isothioureido)ethyl>-6-phenyl-3(2H)-pyridazinone

Base Information

Chemical Name:2-<2-(3-cyano-2-methyl-1-isothioureido)ethyl>-6-phenyl-3(2H)-pyridazinone
CAS No.:79460-70-1
Molecular Formula:C₁₅H₁₅N₅OS
Molecular Weight:313.383
Hs Code.:

Synonyms:2-<2-(3-cyano-2-methyl-1-isothioureido)ethyl>-6-phenyl-3(2H)-pyridazinone

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Chemical Property of 2-<2-(3-cyano-2-methyl-1-isothioureido)ethyl>-6-phenyl-3(2H)-pyridazinone

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Technology Process of 2-<2-(3-cyano-2-methyl-1-isothioureido)ethyl>-6-phenyl-3(2H)-pyridazinone

There total 3 articles about 2-<2-(3-cyano-2-methyl-1-isothioureido)ethyl>-6-phenyl-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 77375-77-0
2-(2-aminoethyl)-6-phenylpyridazin-3(2H)-one

: 10191-60-3
dimethyl N-cyanodithioiminocarbonate

: 79460-70-1
2-<2-(3-cyano-2-methyl-1-isothioureido)ethyl>-6-phenyl-3(2H)-pyridazinone

Guidance literature:: In ethanol; at 0 - 5 ℃; for 2h;
DOI:10.1021/jm00357a012

Reference yield:

: 2166-31-6
6-phenylpyridazin-3(2H)-one

: 79460-70-1
2-<2-(3-cyano-2-methyl-1-isothioureido)ethyl>-6-phenyl-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / K₂CO₃ / various solvent(s) / 6 h / Heating

2: 1.) 100 percent hydrazine hydrate, 2.) 10 percent aq. HCl / 1.) EtOH, reflux, 4 h, 2.) EtOH, reflux, 2 h

3: 82 percent / ethanol / 2 h / 0 - 5 °C

With hydrogenchloride; potassium carbonate; hydrazine hydrate; In ethanol;
DOI:10.1021/jm00357a012

Reference yield:

: 83675-81-4
6-phenyl-2-<2-(phthalimido)ethyl>-3(2H)-pyridazinone

: 79460-70-1
2-<2-(3-cyano-2-methyl-1-isothioureido)ethyl>-6-phenyl-3(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 100 percent hydrazine hydrate, 2.) 10 percent aq. HCl / 1.) EtOH, reflux, 4 h, 2.) EtOH, reflux, 2 h

2: 82 percent / ethanol / 2 h / 0 - 5 °C

With hydrogenchloride; hydrazine hydrate; In ethanol;
DOI:10.1021/jm00357a012