7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1379540-63-2
Molecular Formula:C₁₅H₁₇ClN₆O₂
Molecular Weight:348.792
Hs Code.:

Synonyms:7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

There total 1 articles about 7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79200-57-0
(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride

: 1379540-63-2
7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethanol / 23 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane; water / 69.5 h / 20 °C

3.1: toluene-4-sulfonic acid / 1.25 h

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / Cooling with ice

4.2: 21 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield: 72.0%

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1379540-63-2
7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1380291-25-7
7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-N-(2,4-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 80 ℃; for 22h;

Reference yield:

: 1379540-63-2
7-((3aS,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: ethyl 3-((1r,3s)-3-((cyclobutylmethyl)(((3aR,4R,6R,6aS)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methyl)amino)cyclobutyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 22 h / 80 °C

2: trimethylphosphane / tetrahydrofuran / 1.5 h / 0 - 20 °C

3: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 19 h / 20 °C

4: sodium cyanoborohydride; acetic acid; methanol

With methanol; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trimethylphosphane; acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; butan-1-ol;