N-tert-Butoxy-2-cyclopropyl-2-hydroxy-2-(4-phenoxyphenyl)acetamid

Base Information

• Chemical Name: N-tert-Butoxy-2-cyclopropyl-2-hydroxy-2-(4-phenoxyphenyl)acetamid
• CAS No.: 162405-22-3
• Molecular Formula: C₂₁H₂₅NO₄
• Molecular Weight: 355.434
• Mol file: 162405-22-3.mol

Synonyms:N-tert-Butoxy-2-cyclopropyl-2-hydroxy-2-(4-phenoxyphenyl)acetamid

Chemical Property of N-tert-Butoxy-2-cyclopropyl-2-hydroxy-2-(4-phenoxyphenyl)acetamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-Butoxy-2-cyclopropyl-2-hydroxy-2-(4-phenoxyphenyl)acetamid

There total 3 articles about N-tert-Butoxy-2-cyclopropyl-2-hydroxy-2-(4-phenoxyphenyl)acetamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

cyclopropylmagnesium bromide (23719-80-4) + N-tert-Butoxy-(4-phenoxyphenyl)glyoxylamid (162405-25-6) → N-tert-Butoxy-2-cyclopropyl-2-hydroxy-2-(4-phenoxyphenyl)acetamid (162405-22-3)

Guidance literature:

In diethyl ether; for 1h; Heating;

Reference yield:

(4-Phenoxy)phenylglyoxylsaeure (79478-16-3) → N-tert-Butoxy-2-cyclopropyl-2-hydroxy-2-(4-phenoxyphenyl)acetamid (162405-22-3)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂

2: 48 percent / NaHCO₃ / diethyl ether; H₂O / 0.5 h / Ambient temperature

3: 84 percent / diethyl ether / 1 h / Heating

With thionyl chloride; sodium hydrogencarbonate; In diethyl ether; water;

Reference yield:

2-oxo-2-(4-phenoxyphenyl)acetyl chloride (129168-44-1) → N-tert-Butoxy-2-cyclopropyl-2-hydroxy-2-(4-phenoxyphenyl)acetamid (162405-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / NaHCO₃ / diethyl ether; H₂O / 0.5 h / Ambient temperature

2: 84 percent / diethyl ether / 1 h / Heating

With sodium hydrogencarbonate; In diethyl ether; water;

upstream raw materials:

cyclopropylmagnesium bromide

N-tert-Butoxy-(4-phenoxyphenyl)glyoxylamid

(4-Phenoxy)phenylglyoxylsaeure

2-oxo-2-(4-phenoxyphenyl)acetyl chloride