2-[(2-Ethoxycarbonyl-acetyl)-phenyl-amino]-benzoic acid ethyl ester

Base Information

• Chemical Name: 2-[(2-Ethoxycarbonyl-acetyl)-phenyl-amino]-benzoic acid ethyl ester
• CAS No.: 1026402-89-0
• Molecular Formula: C₂₀H₂₁NO₅
• Molecular Weight: 355.39
• Mol file: 1026402-89-0.mol

Synonyms:2-[(2-Ethoxycarbonyl-acetyl)-phenyl-amino]-benzoic acid ethyl ester

Chemical Property of 2-[(2-Ethoxycarbonyl-acetyl)-phenyl-amino]-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-[(2-Ethoxycarbonyl-acetyl)-phenyl-amino]-benzoic acid ethyl ester

There total 1 articles about 2-[(2-Ethoxycarbonyl-acetyl)-phenyl-amino]-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(phenylamino)benzoate (23868-11-3) + ethyl chlorocarbonylacetate (36239-09-5) → 2-[(2-Ethoxycarbonyl-acetyl)-phenyl-amino]-benzoic acid ethyl ester (1026402-89-0)

Guidance literature:

With triethylamine; In dichloromethane; for 8h; Ambient temperature;

DOI:10.1007/BF01169641

Reference yield: 74.0%

2-[(2-Ethoxycarbonyl-acetyl)-phenyl-amino]-benzoic acid ethyl ester (1026402-89-0) → ethyl [4-hydroxy-2-oxo-1-phenyl-1,2-dihydro-3-quinoline]carboxylate (64675-79-2)

Guidance literature:

With sodium ethanolate; In ethanol;

DOI:10.1007/BF01169641

Reference yield:

2-[(2-Ethoxycarbonyl-acetyl)-phenyl-amino]-benzoic acid ethyl ester (1026402-89-0) → 4-hydroxy-1-phenyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / EtONa / ethanol

2: 95 percent / 2N aq. HCl / 5 h / Heating

With hydrogenchloride; sodium ethanolate; In ethanol;

DOI:10.1007/BF01169641

upstream raw materials:

ethyl 2-(phenylamino)benzoate

ethyl chlorocarbonylacetate

Downstream raw materials:

ethyl [4-hydroxy-2-oxo-1-phenyl-1,2-dihydro-3-quinoline]carboxylate