(-)-(S)-8-(4-methoxyphenyl)-1,13-bis[(4-methylphenyl)sulfonyl]-1,5,9,13-tetraazacycloheptadecan-6-one

Base Information

Chemical Name:(-)-(S)-8-(4-methoxyphenyl)-1,13-bis[(4-methylphenyl)sulfonyl]-1,5,9,13-tetraazacycloheptadecan-6-one
CAS No.:373360-25-9
Molecular Formula:C₃₄H₄₆N₄O₆S₂
Molecular Weight:670.894
Hs Code.:

Synonyms:(-)-(S)-8-(4-methoxyphenyl)-1,13-bis[(4-methylphenyl)sulfonyl]-1,5,9,13-tetraazacycloheptadecan-6-one

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Chemical Property of (-)-(S)-8-(4-methoxyphenyl)-1,13-bis[(4-methylphenyl)sulfonyl]-1,5,9,13-tetraazacycloheptadecan-6-one

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Technology Process of (-)-(S)-8-(4-methoxyphenyl)-1,13-bis[(4-methylphenyl)sulfonyl]-1,5,9,13-tetraazacycloheptadecan-6-one

There total 10 articles about (-)-(S)-8-(4-methoxyphenyl)-1,13-bis[(4-methylphenyl)sulfonyl]-1,5,9,13-tetraazacycloheptadecan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 110-52-1
1,4-dibromo-butane

: 124-38-9,18923-20-1
carbon dioxide

: 321835-85-2
(-)-(S)-3-(4-methoxyphenyl)-N-{3-[(4-methylphenylsulfonyl)amino]propyl}-3-({3-[(4-methylphenylsulfonyl)amino]propyl}amino)propanamide

: 373360-25-9
(-)-(S)-8-(4-methoxyphenyl)-1,13-bis[(4-methylphenyl)sulfonyl]-1,5,9,13-tetraazacycloheptadecan-6-one

: 9-(4-bromobutyl)-8-(4-methoxyphenyl)-6-oxo-1,13-(4-tolylsulfonyl)-1,5,9,13-tetraazacycloheptadecane-5-carboxylic acid

Guidance literature:: carbon dioxide; (-)-(S)-3-(4-methoxyphenyl)-N-{3-[(4-methylphenylsulfonyl)amino]propyl}-3-({3-[(4-methylphenylsulfonyl)amino]propyl}amino)propanamide; With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 1.33333h;

1,4-dibromo-butane; In N,N-dimethyl-formamide; at 20 ℃; for 30h;
DOI:10.1002/1522-2675(20010711)84:7<2108::AID-HLCA2108>3.0.CO;2-G

Reference yield: 83.0%

: 110-52-1
1,4-dibromo-butane

: 321835-85-2
(-)-(S)-3-(4-methoxyphenyl)-N-{3-[(4-methylphenylsulfonyl)amino]propyl}-3-({3-[(4-methylphenylsulfonyl)amino]propyl}amino)propanamide

: 373360-25-9
(-)-(S)-8-(4-methoxyphenyl)-1,13-bis[(4-methylphenyl)sulfonyl]-1,5,9,13-tetraazacycloheptadecan-6-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(200204)85:4<979::AID-HLCA979>3.0.CO;2-F

Reference yield:

: 444119-31-7
4-methyl-N-{3-[(methylsulfonyl)oxy]propyl}benzenesulfonamide

: 373360-25-9
(-)-(S)-8-(4-methoxyphenyl)-1,13-bis[(4-methylphenyl)sulfonyl]-1,5,9,13-tetraazacycloheptadecan-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / Et₃N / acetonitrile / 4 h / Heating

2: 90 percent / Cu(Ac)2 / 24 h / 20 °C

3: 90 percent / Et₃N / CHCl₃ / 0.5 h / 0 °C

4: 83 percent / Cs₂CO₃ / dimethylformamide

With caesium carbonate; triethylamine; copper diacetate; In chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/1522-2675(200204)85:4<979::AID-HLCA979>3.0.CO;2-F