methyl (S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoate

Base Information

• Chemical Name: methyl (S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoate
• CAS No.: 145058-07-7
• Molecular Formula: C₁₅H₁₇NO₃S
• Molecular Weight: 291.371
• Mol file: 145058-07-7.mol

Synonyms:methyl (S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoate

Chemical Property of methyl (S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoate

There total 2 articles about methyl (S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoic acid (145057-99-4) → methyl (S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoate (145058-07-7)

Guidance literature:

With thionyl chloride; for 1h; Heating;

DOI:10.1246/bcsj.65.2359

Reference yield:

(R)-2-<(2-hydroxy-1-phenylethyl)amino>-2-(2-thienyl)ethanenitrile (145057-92-7,145057-93-8) → methyl (S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoate (145058-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / aq. HCl / 1.) RT, 16 h, 2.) 80 deg C, 30 min

2: 100 percent / thionyl chloride / 1 h / Heating

With hydrogenchloride; thionyl chloride;

DOI:10.1246/bcsj.65.2359

Reference yield:

methyl (S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoate (145058-07-7) → (R)-amino(thiophen-2-yl)acetic acid (4052-59-9,21124-40-3,43189-45-3,61261-51-6,65058-23-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Pb(OAc)4 / CH₂Cl₂; methanol / 0.05 h

2: 6 M aq. HCl / 1.) RT, 18 h, 2.) 50 deg C, 1 h, 3.) 110, 45 min

With lead(IV) acetate; hydrogenchloride; In methanol; dichloromethane;

DOI:10.1246/bcsj.65.2359

upstream raw materials:

methanol

(S)-2-<(R)-2-hydroxy-1-phenylethylamino>-2-(2-thienyl)ethanoic acid

(R)-2-<(2-hydroxy-1-phenylethyl)amino>-2-(2-thienyl)ethanenitrile

Downstream raw materials:

(R)-amino(thiophen-2-yl)acetic acid

(2S)-amino(2-thienyl)acetic acid